Naslov
Lead effect on blood pressure in moderately lead-exposed male workers

Autori
Telišman, Spomenka ; Pizent, Alica ; Jurasović, Jasna ; Cvitković, Petar

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Scientific Programme and Abstracts / - , 2000

Skup
26th International Congress on Occupational Health

Mjesto i datum
Singapur, 27.08.2000. - 01.09.2000

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Sažetak
Aim. As lead (Pb) effect on human blood pressure (BP) is still controversial, the study considers possible interaction of relevant toxic and/or essential metals and a role of potential confounders in increasing BP in men. Method. In 151 healthy male industrial workers, aged 20-43 years, comprising 100 subjects with slight to moderate occupational Pb-exposure and 51 reference subjects, the following variables were measured: blood Pb (B-Pb), activity of delta-aminolevulinic acid dehydratase (ALAD), erythrocyte protoporphyrin (EP), blood cadmium (B-Cd), serum zinc (S-Zn), serum copper (S-Cu), body mass index (BMI), hematocrit (Hct), and systolic and diastolic BP (SBP, DBP). The interrelationship of any of the biomarkers of Pb (B-Pb, ALAD, EP) and possible confounding variables (B-Cd, S-Zn, S-Cu, BMI, Hct, smoking, alcohol, age) to SBP and DBP was evaluated by multiple regression analysis. Results. Median and range B-Pb values were 367 (99-659) ľg/L in Pb-workers and 103 (67-208) ľg/L in reference subjects (P<0.0001). The Pb-workers had been occupationally exposed to Pb for 5 (2-21) years. A significantly higher EP and lower ALAD was found in Pb-workers compared to reference subjects (P<0.0001), while there was no significant difference in the other measured variables. The multiple regression analyses showed that BMI was a significant predictor of increased SBP in Pb-workers (P<0.01) and all subjects (P<0.005), and of increased DBP in Pb-workers (P<0.005) and all subjects (P<0.0005). In addition, EP was a significant predictor of increased SBP in Pb-workers (P<0.01) and all subjects (P<0.05), and of increased DBP in all subjects (P=0.05) while this was marginally significant in Pb-workers (P<0.10). A decrease in ALAD was a significant predictor of increased DBP in all subjects (P<0.05), and a marginally significant predictor of increased SBP in Pb-workers (P<0.10). No significant association between B-Pb (either original, log-transformed, or corrected for Hct) and SBP and DBP was found. This may partly be ascribed to a fluctuating Pb-exposure in Pb-workers. Conclusion. Even moderate exposure to Pb can significantly contribute to an increase in BP in men. As EP and ALAD are known to better reflect long-term cumulative Pb-exposure, while B-Pb mainly reflects current or recent exposure level of an individual, cumulative Pb exposure appears to be relevant in increasing BP in humans.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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