Naslov
Kinetics of tissue iron in experimental autoimmune encephalomyelitis in rats

Autori
Milin, Čedomila ; Tota, Marin ; Čanadi-Jurešić, Gordana ; Grebić, Damir ; Radošević-Stašić, Biserka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
NeuroImmunoModulation Vol.18/6 2011. NeuroImmunoModulation in Health and Disease: An Integrative Biomedical Approach / Del Rey Adriana and Kolbe, Ina - Basel : Karger Publishers, 2011, 392-392

Skup
8th Congress of the international Society for NeuroimmunoModulation (ISNIM) with the German Endocrine-Brain-Immune Network (GEBIN)

Mjesto i datum
Dresden, Njemačka, 22.10.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
iron; CR-EAE; DA rats

Sažetak
To elucidate the role of iron in the pathomechanisms of autoimmune CNS disorders we estimated the tissue concentrations of Fe2+ in the brain, spinal cord (SC) and liver in monophasic and chronic relapsing (CR) forms of experimental autoimmune encephalomyelitis (EAE), induced in Dark Agouti (DA) strain of rats, by subcutaneous injection of myelin basic protein (MBP) in complete Freund’s adjuvant (CFA) or by bovine brain homogenate (BBH) in CFA, respectively. Control rats were treated with CFA or with saline solution. The data obtained by clinical assessment and by inductively coupled plasma spectrometry have shown that in both monophasic EAE and in CR-EAE the attacks of disease were followed by high accumulation of iron in the liver (on the 12th post-immunization day, and on the 12th and the 22nd day). Simultaneously, in monophasic EAE decreased the concentration of Fe2+ in the brain (during the remission phase) and in the cervical spinal cord (during attacks and remission). Similarly, in CR-EAE the lower iron content was found in cervical spinal cord during the second attack of disease. The data point to regulatory effects of iron and hepatic trace elements in the pathogenesis of EAE.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA