Pregled bibliografske jedinice broj: 52823
Azithromycin: clinical safety and tolerability
Azithromycin: clinical safety and tolerability // 21st International Congres of Chemotherapy
Berlin, Njemačka, 1999. (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 52823 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Azithromycin: clinical safety and tolerability
Autori
Barsic, B ; Banaszak, A.M. ; Matrapazovski M. ; Klinar, I.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
21st International Congres of Chemotherapy
/ - , 1999
Skup
9th European Congress of Clinical
Microbiology and Infectious Diseases
Mjesto i datum
Berlin, Njemačka, 21.03.1999. - 24.03.1999
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
azithromycin; clinical safety; tolerability
Sažetak
Objectives: In order to assess the tolerability of azithromycin and
compare it to the tolerability of other antibiotics we analyzed safety
data from 23 comparative and 35 non-comparative clinical trials.
Methods: The majority of adult patients received azithromycin in
a total dose of 1.5 g given for 3 or 5 days, patients with
urethritis/cervicitis received a single 1-g dose, patients with erythema
migrans a total dose of 34.5 g, and Helicobacter pylori-positive patients
with peptic ulcer or gastritis up to 7 g.
Results: Side effects were recorded in 5.6% of 3576 adults and
6.5% of 1151 children treated with azithromycin, and in 13.9% of
936 adults and 17.6% of 408 children treated with other antibiotics
(P50.001). Treatment was discontinued due to side effects in 0.1%
of adults and 0.4% of children treated with azithromycin, and in 2.6%
of adults and 2.0% of children treated with other antibiotics
(P50.001). Laboratory abnormalities were observed in 7.1% of adults
and 4.0% of children treated with azithromycin, and in 5.8% of adults
and 2.4% of children treated with other antibiotics (p 0.05).
Conclusions: Presented results show that azithromycin is toler-ated
equally or better than other antibiotics, in both adults and chil-dren.
Side effects, mostly gastrointestinal, are mild in severity and
very rarely require discontinuation of the treatment. The most
common laboratory abnormalities were transient eosinophilia and
elevation of liver enzymes.
Izvorni jezik
Engleski
Znanstvena područja
Javno zdravstvo i zdravstvena zaštita
