Naslov
Glycolipoprotein extract of eisenia foetida as wound healing agent

Autori
Grdiša, Mira ; Popović, Maja ; Hrženjak, Terezija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Sažeci sa skupa Treći hrvatski kongres medicinskih biokemičara ; u: Biochemia Medica 9 (1999)1/2 / Stavljenić-Rukavina, Ana - Zagreb : Društvo hrvatskih medicinskih biokemičara, 1999, 58-58

Skup
Hrvatski kongres medicinskih biokemičara (3 ; 1999)

Mjesto i datum
Vukovar, Hrvatska, 19.09.1999. - 24.09.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
G-90; earthworm; wound healing

Sažetak
The glycolipoprotein extract (G-90) obtained from tissue homogenate of eartworm Eisenia foetida has many biological characteristcs, which are usfull in wound healing process. This extract showed interaction with biological materials from evolutionary more developed species. These materials include serums, erythrocytes, normal and transformed cells in culture of birds and mammals. The extract has also lectine activity. depending on the concentration, it acts as agglutinin, hemagglutinin, mitogen, anticoagulant, fibrinolytic and intermediate agent in cell impulse transmission. Part of the structures responsible for described activites are isolated and characterized (chemically and biologically). These structures are growth factors belonging to insulin superfamilly, adhesins � integrins from immunoglobulin superfamilly and serine proteases with tripsin code with fibrinolytic and anticoagulant activitis. Based on the our research work and those from literature data about regenerative ability of earthworm, we developed an idea that G-90 contains the structure and qualities requiredfor � in vivo� tissue regeneration process i.e. wound healing. The macromolecular mixture G-90 in nanograms and micrograms concentration stimulates proliferation of the cells, depending on the type. In terapeutic concentrations G-90 is not toxic, allergenic, mutagen nor carcinogen. It has strong antibacterial activity � in vivo� and � in vitro� . G-90 protected cells in culture from oxidative damage, caused by hydrogen peroxide. G-90 stimulates cellular immune system. As fibrinolytic and anticoagulant it can participate in an active maintenance of homeostasis. G-90 stimulates speed and quality of wound healing by containing some growth factors, and stimulation of synthesis of others. In comparison withphysiologicalprocesses of wound healing, G-90 stimulates proliferation of fibroblasts and epithelial cells in the wounds, as well as differentiation of these cells.

Izvorni jezik
Engleski

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