Pregled bibliografske jedinice broj: 526283
Synthesis of 3-(o-stilbenyl)sydnone and 3-(o-stilbenyl)-4-substituted-sydnone derivatives and their antitumor evaluation
Synthesis of 3-(o-stilbenyl)sydnone and 3-(o-stilbenyl)-4-substituted-sydnone derivatives and their antitumor evaluation // ARKIVOC, 2011 (2011), 10; 1-15 doi:10.3998/ark.5550190.0012.a01 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 526283 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis of 3-(o-stilbenyl)sydnone and 3-(o-stilbenyl)-4-substituted-sydnone derivatives and their antitumor evaluation
Autori
Butković, Kristina ; Marinić, Željko ; Šindler-Kulyk, Marija
Izvornik
ARKIVOC (1551-7004) 2011
(2011), 10;
1-15
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
stilbenes ; sydnones ; synthesis ; antitumor evaluation
Sažetak
A series of novel stilbene-sydnone derivatives were synthesized by the following sequence of reactions: starting from methyl anthranilate via glycine- and nitrosoglycine derivatives the corresponding 3-(o-carbomethoxyphenyl)-4-H/Me/Ph-sydnones were prepared and transformed to 3-(o-formylphenyl)-4-H/Me/Ph-sydnones, starting materials for Wittig reaction with various phosphonium salts to stilbenylsydnone derivatives. Final products were evaluated for their cytotoxic properties on five cancer cell lines, whereby the cis-4-methyl-3-[2-[2-(4-methylphenyl)ethenyl]phenyl]sydnone (5) and cis-4-phenyl-3-[2-[2-(4-chlorophenyl)ethenyl]-phenyl]sydnone (10) showed the most pronounced activity.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
125-0982933-2926 - Heteropolicikli, strukturne osnove za bioaktivne spojeve. Sinteza i fotokemija (Škorić, Irena, MZOS ) ( CroRIS)
098-0982929-2917 - Spektroskopija NMR i modeliranje bioaktivnih molekula (Plavšić, Dejan, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
