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Pregled bibliografske jedinice broj: 525901

Novel linear diamine disubstituted polycyclic ‘cage’ derivatives as potential anti-mycobacterial candidates

Onajole, K. Oluseye; Sosibo, Sphelele; Govender, Patrick; Govender, Thavendran; Van Helden Paul D.; Maguire, Glen E. M.; Mlinarić-Majerski, Kata; Wiid, Ian; Kruger, Hendrik G.
Novel linear diamine disubstituted polycyclic ‘cage’ derivatives as potential anti-mycobacterial candidates // Chemical biology & drug design, 78 (2011), 6; 1022-1030 doi:10.0000/j.1747-0285.2011.01242.x (međunarodna recenzija, članak, znanstveni)

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Naslov
Novel linear diamine disubstituted polycyclic ‘cage’ derivatives as potential anti-mycobacterial candidates

Autori
Onajole, K. Oluseye ; Sosibo, Sphelele ; Govender, Patrick ; Govender, Thavendran ; Van Helden Paul D. ; Maguire, Glen E. M. ; Mlinarić-Majerski, Kata ; Wiid, Ian ; Kruger, Hendrik G.

Izvornik
Chemical biology & drug design (1747-0277) 78 (2011), 6; 1022-1030

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
anti-tuberculosis activity; SQ109; pentacyclodecane; pentacycloundecane and tricyclodecane; isoprenyl diamine

Sažetak
As part of an ongoing project to develop highly potent anti-tuberculosis therapeutics, a series novel polycyclic ‘cage’ tetra-amines were synthesized and screened for in-vitro antituberculosis activities against the H37Rv strain of tuberculosis. Three disubstituted polycyclic moieties, namely pentacyclodecane, pentacycloundecane (PCU), and tricyclodecane were used in this study. Compounds 5 and 7 showed similar activity to SQ109 at a MIC of 1 μM while compounds 4, 6 and 8 displayed MIC activity at 1<MIC<10 μM. This study demonstrates the first reported analysis of pentacyclo[5.3.0.02, 5.03, 9.04, 8]decane as a potential therapeutic agent.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
098-0982933-2911 - Kavezasti spojevi: ugradbene jedinice u molekularnim sustavima (Majerski, Kata, MZOS ) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Kata Majerski (autor)

Poveznice na cjeloviti tekst rada:

doi onlinelibrary.wiley.com

Citiraj ovu publikaciju:

Onajole, K. Oluseye; Sosibo, Sphelele; Govender, Patrick; Govender, Thavendran; Van Helden Paul D.; Maguire, Glen E. M.; Mlinarić-Majerski, Kata; Wiid, Ian; Kruger, Hendrik G.
Novel linear diamine disubstituted polycyclic ‘cage’ derivatives as potential anti-mycobacterial candidates // Chemical biology & drug design, 78 (2011), 6; 1022-1030 doi:10.0000/j.1747-0285.2011.01242.x (međunarodna recenzija, članak, znanstveni)
Onajole, K., Sosibo, S., Govender, P., Govender, T., Van Helden Paul D., Maguire, G., Mlinarić-Majerski, K., Wiid, I. & Kruger, H. (2011) Novel linear diamine disubstituted polycyclic ‘cage’ derivatives as potential anti-mycobacterial candidates. Chemical biology & drug design, 78 (6), 1022-1030 doi:10.0000/j.1747-0285.2011.01242.x.
@article{article, author = {Onajole, K. Oluseye and Sosibo, Sphelele and Govender, Patrick and Govender, Thavendran and Maguire, Glen E. M. and Mlinari\'{c}-Majerski, Kata and Wiid, Ian and Kruger, Hendrik G.}, year = {2011}, pages = {1022-1030}, DOI = {10.0000/j.1747-0285.2011.01242.x}, keywords = {anti-tuberculosis activity, SQ109, pentacyclodecane, pentacycloundecane and tricyclodecane, isoprenyl diamine}, journal = {Chemical biology and drug design}, doi = {10.0000/j.1747-0285.2011.01242.x}, volume = {78}, number = {6}, issn = {1747-0277}, title = {Novel linear diamine disubstituted polycyclic ‘cage’ derivatives as potential anti-mycobacterial candidates}, keyword = {anti-tuberculosis activity, SQ109, pentacyclodecane, pentacycloundecane and tricyclodecane, isoprenyl diamine} }
@article{article, author = {Onajole, K. Oluseye and Sosibo, Sphelele and Govender, Patrick and Govender, Thavendran and Maguire, Glen E. M. and Mlinari\'{c}-Majerski, Kata and Wiid, Ian and Kruger, Hendrik G.}, year = {2011}, pages = {1022-1030}, DOI = {10.0000/j.1747-0285.2011.01242.x}, keywords = {anti-tuberculosis activity, SQ109, pentacyclodecane, pentacycloundecane and tricyclodecane, isoprenyl diamine}, journal = {Chemical biology and drug design}, doi = {10.0000/j.1747-0285.2011.01242.x}, volume = {78}, number = {6}, issn = {1747-0277}, title = {Novel linear diamine disubstituted polycyclic ‘cage’ derivatives as potential anti-mycobacterial candidates}, keyword = {anti-tuberculosis activity, SQ109, pentacyclodecane, pentacycloundecane and tricyclodecane, isoprenyl diamine} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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