Naslov
Brain plasticity after perinatal damage-prospective neurodevelopmental and ultrasonographic/magnetic resonance study

Autori
Mejaški-Bošnjak, Vlatka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Ultrasound in Obstetrics & Gynecology / Kurjak, A ; Kupešić, S ; Latin, V ; Radocj, D ; Cerovec J - Zagreb, 2000

Skup
10th World Congress on Ultrasound in Obstetrics and Gynecology

Mjesto i datum
Zagreb, Hrvatska, 04.10.2000. - 07.10.2000

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Sažetak
Objective: To assess long-term neurodevelopmental outcome and structural reorganization of children suffering hypoxic-ischemic (H-I) and/or haemorrhagic perinatal brain damage ; To test the hypothesis of more successful recovery of prematures and/or unilateral lesions after perinatal brain damage ; To estimate prenatal events, in particularly value of pathological findings of Color Doppler (CD) in the pathogenesis of perinatal brain damage ; Study design: 68 children suffering perinatal brain H-I (10) and/or haemorrhagic lesions (58) diagnosed by ultrasonography (US) underwent neurologic and psycho-linguistic examinations by age 16. High resolution 2 T MRI was used to assess structural reorganization ; 20 children suffering unilateral perinatal brain damage (MCA infarct) were followed-up (neurodevelopmentally, transcranial CD and US/CT, MRI) ; 25 children with CD findings (C/U ratio under 1 during pregnancy) underwent prospective follow-up postnatally by age 2. Results: All children with H-I lesions have still at the age 16 one or more severe handicaps, while 39 children with mild grade of haemorrhage had minor neurological dysfunction, 15 were normal. MRI revealed destructive and/or atrophic lesions in all children with H-I lesions and mild atrophy and/or signs of periventricular haemorrhage in rest children. 20 children with unilateral perinatal brain damage have contralateral hemiparesis and various accompanying neurodevelopmental disorders. There were no strict correlation between size, site, hemispheral involvement, gestational age and neurodevelopmental outcome of children examined. Out of 25 children having pathological CD findings during pregnancy 7 revealed mild grade (I-II) of periventricular haemorrhage, 10 children isolated of combined H-I and haemorrhagic lesion, 7 children have no apparent perinatal brain damage. Short-term neurodevelopmental outcome revealed mild delay and/or disorders in 10 children and in the rest the normal status.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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