Naslov
β-BUTIROLACTONES WITH ADAMANTANE MOIETY SEARCHING FOR NOVEL BIOACTIVE β-LACTONES

Autori
Matković, Marija ; Mlinarić-Majerski, Kata

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
4th European Conference on Chemistry for Life Sciences / 4ECCLS / - Budimpešta, 2011

Skup
4th European Conference on Chemistry for Life Sciences / 4ECCLS

Mjesto i datum
Budimpešta, Mađarska, 31.08.2011. - 03.09.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
β-aminoacids; adamantyl-substituted β-butyrolactones and β-lactones

Sažetak
Alongside the well known β-lactams, literature also describes their O-analogs, β-lactons, as structural entities that bring up biological activity. Furtheron, β-lactons are usefull precursors in organic synthesis such as in the preparation of allenes or β-aminoacids. Therefore the convenient synthetic route of preparing these interesting four memberd heterocycles, differently substituted, has occurred as an object of investigation. The fact that the adamantane moiety is present as a pharmacophoric group in different therapeutic agents makes idea of preparing adamantyl-substituted β-lactones quite intriguing. Herein we present a simple method of preparing adamantyl-substituted β-butyrolactones 1 and 2 as well as their structural elucidation. The reactivity of these molecules towards the ring opening will also be discussed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA