Naslov
Commentary : Bullous Skin Diseases

Autori
Lipozenčić, Jasna ; Marinović, Branka

Izvornik
Clinics in dermatology (0738-081X) 29 (2011), 4; 353-354

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, uvodnik, znanstveni

Ključne riječi
commentary; bullous skin diseases; pemphigus group

Sažetak
Bullous dermatoses are characterized by vesicular-pustular eruptions and are classified as to whether they are hereditary or acquired diseases. The most important of the acquired bullous skin diseases are the pemphigus group, the pemphigoid group, acquired bullous epidermolysis, and dermatitis herpetiformis. Pemphigus is a group of autoimmune blistering diseases of the skin and mucous membranes mediated by immunoglobulin G (IgG) antibodies against the cadherin type of cell-cell adhesion molecules in desmosomes, desmogleins. Pemphigus group consists of three major forms: pemphigus vulgaris, pemphigus foliaceus (have IgG antibodies against desmoglein 3 and 1) and paraneoplastic pemphigus (IgG antibodies against plectin molecules in addition of desmogleins). For successful treatment of pemphigus, one must reduce autoantibody production, while blocking any of the several steps in the inflammatory cascade can treat bullous pemphigoid. Keeping the patient alive by suppressing disease, maintaining the quality of life, and minimizing drug side effects are major goals for the treatment of bullous skin diseases. When EBA is diagnosed, it is imperative to consider complications of disease and association with other inflammatory conditions that are frequently associated with EBA. Immunosuppressive therapy is usually required. Because neutrophils are important effector cells that mediate tissue damage in IgA dermatoses, responsiveness exhibit to sulfone therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA