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Pregled bibliografske jedinice broj: 523768

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Kilpeläinen, Tuomas O.; Zillikens, M. Carola; Stančákova, Alena; Finucane, Francis M.; Ried, Janina S.; Langenberg, Claudia; Zhang, Weihua; Beckmann, Jacques S.; Luan, Jian'an; Vandenput, Liesbeth et al.
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile // Nature genetics, 43 (2011), 8; 753-760 doi:10.1038/ng.866 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 523768 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Autori
Kilpeläinen, Tuomas O. ; Zillikens, M. Carola ; Stančákova, Alena ; Finucane, Francis M. ; Ried, Janina S. ; Langenberg, Claudia ; Zhang, Weihua ; Beckmann, Jacques S. ; Luan, Jian'an ; Vandenput, Liesbeth ; Styrkarsdottir, Unnur ; Zhou, Yanhua ; Smith, Albert Vernon ; Zhao, Jing-Hua ; Amin, Najaf ; Vedantam, Sailaja ; Shin, So Youn ; Haritunians, Talin ; Fu, Mao ; Feitosa, Mary F. ; Kumari, Meena ; Halldorsson, Bjarni V. ; Tikkanen, Emmi ; Mangino, Massimo ; Hayward, Caroline ; Song, Ci ; Arnold, Alice M. ; Aulchenko, Yurii S. ; Oostra, Ben A. ; Campbell, Harry ; Cupples, Adrienne L. ; Davis, Kathryn E. ; Döring, Angela ; Eiriksdottir, Gudny ; Estrada, Karol ; Fernández-Real, Jose Manuel ; Garcia, Melissa ; Gieger, Christian ; Glazer, Nicole L. ; Guiducci, Candace ; Hofman, Albert ; Humphries, Steve E. ; Isomaa, Bo ; Jacobs, Leonie C. ; Jula, Antti ; Karasik, David ; Karlsson, Magnus K. ; Khaw, Kay-Tee ; Kim, Lauren J. ; Kivimäki, Mika ; Klopp, Norman ; Kühnel, Brigitte ; Kuusisto, Johanna ; Liu, Yongmei ; Ljunggren, Osten ; Lorentzon, Mattias ; Luben, Robert N. ; McKnight, Barbara ; Mellström, Dan ; Mitchell, Braxton D. ; Mooser, Vincent ; Moreno, Jose Maria ; Männistö, Satu ; O'Connell, Jeffery R. ; Pascoe, Laura ; Peltonen, Leena ; Peral, Belen ; Perola, Markus ; Psaty, Bruce M. ; Salomaa, Veikko ; Savage, David B. ; Semple, Robert K. ; Škarić-Jurić, Tatjana ; Sigurdsson, Gunnar ; Song, Kijoung S. ; Spector, Timothy D. ; Syvänen, Ann-Christine ; Talmud, Philippa J. ; Thorleifsson, Gudmar ; Thorsteinsdottir, Unnur ; Uitterlinden, Andre G. ; van Duijn, Cornelia M. ; Vidal-Puig, Antonio ; Wild, Sarah H. ; Wright, Alan F. ; Clegg, Deborah J. ; Schadt, Eric ; Wilson, James F. ; Rudan, Igor ; Ripatti, Samuli ; Borecki, Ingrid B. ; Shuldiner, Alan R. ; Ingelsson, Erik ; Jansson, John-Olov ; Kaplan, Robert C. ; Gudnason, Vilmundur ; Harris, Tamara B. ; Groop, Leif ; Kie, Douglas P. ; Rivadeneira, Fernando ; Walker, Mark ; Barroso, Ines ; Vollenweider, Peter ; Waeber, Gerard ; Chambers, John C. ; Kooner, Jaspal S. ; Soranzo, Nicole ; Hirschhorn, Joel N. ; Stefansson, Kari ; Wichmann, H.-Erich ; Ohlsson, Claes ; O'Rahilly, Stephen ; Wareham, Nicholas J. ; Speliotes, Elizabeth K. ; Fox, Caroline S. ; Laakso, Markku ; Loos, Ruth J.F.

Izvornik
Nature genetics (1061-4036) 43 (2011), 8; 753-760

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
genome-wide association study; meta-analysis; fat distribution; adiposity; dyslipidemia; insulin resistance

Sažetak
Genome-wide association studies have identified 32 loci influencing body mass index, but this measure does not distinguish lean from fat mass. To identify adiposity loci, we meta-analyzed associations between ∼2.5 million SNPs and body fat percentage from 36, 626 individuals and followed up the 14 most significant (P < 10(-6)) independent loci in 39, 576 individuals. We confirmed a previously established adiposity locus in FTO (P = 3 × 10(-26)) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × 10(-11)) and one near SPRY2 (P = 3 × 10(-8)). Both loci contain genes with potential links to adipocyte physiology. Notably, the body-fat-decreasing allele near IRS1 is associated with decreased IRS1 expression and with an impaired metabolic profile, including an increased visceral to subcutaneous fat ratio, insulin resistance, dyslipidemia, risk of diabetes and coronary artery disease and decreased adiponectin levels. Our findings provide new insights into adiposity and insulin resistance.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija



POVEZANOST RADA

Projekti:
196-1962766-2747 - Kompleksna obilježja i zdravlje stanovništva od djetinjstva do duboke starosti (Smolej-Narančić, Nina, MZOS ) ( CroRIS)
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Institut za antropologiju,
Medicinski fakultet, Split

Profili:

Avatar Url Tatjana Škarić-Jurić (autor)

Avatar Url Igor Rudan (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

Kilpeläinen, Tuomas O.; Zillikens, M. Carola; Stančákova, Alena; Finucane, Francis M.; Ried, Janina S.; Langenberg, Claudia; Zhang, Weihua; Beckmann, Jacques S.; Luan, Jian'an; Vandenput, Liesbeth et al.
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile // Nature genetics, 43 (2011), 8; 753-760 doi:10.1038/ng.866 (međunarodna recenzija, članak, znanstveni)
Kilpeläinen, T., Zillikens, M., Stančákova, A., Finucane, F., Ried, J., Langenberg, C., Zhang, W., Beckmann, J., Luan, J. & Vandenput, L. (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nature genetics, 43 (8), 753-760 doi:10.1038/ng.866.
@article{article, author = {Kilpel\"{a}inen, Tuomas O. and Zillikens, M. Carola and Stan\v{c}\'{a}kova, Alena and Finucane, Francis M. and Ried, Janina S. and Langenberg, Claudia and Zhang, Weihua and Beckmann, Jacques S. and Luan, Jian'an and Vandenput, Liesbeth and Styrkarsdottir, Unnur and Zhou, Yanhua and Smith, Albert Vernon and Zhao, Jing-Hua and Amin, Najaf and Vedantam, Sailaja and Shin, So Youn and Haritunians, Talin and Fu, Mao and Feitosa, Mary F. and Kumari, Meena and Halldorsson, Bjarni V. and Tikkanen, Emmi and Mangino, Massimo and Hayward, Caroline and Song, Ci and Arnold, Alice M. and Aulchenko, Yurii S. and Oostra, Ben A. and Campbell, Harry and Cupples, Adrienne L. and Davis, Kathryn E. and D\"{o}ring, Angela and Eiriksdottir, Gudny and Estrada, Karol and Fern\'{a}ndez-Real, Jose Manuel and Garcia, Melissa and Gieger, Christian and Glazer, Nicole L. and Guiducci, Candace and Hofman, Albert and Humphries, Steve E. and Isomaa, Bo and Jacobs, Leonie C. and Jula, Antti and Karasik, David and Karlsson, Magnus K. and Khaw, Kay-Tee and Kim, Lauren J. and Kivim\"{a}ki, Mika and Klopp, Norman and K\"{u}hnel, Brigitte and Kuusisto, Johanna and Liu, Yongmei and Ljunggren, Osten and Lorentzon, Mattias and Luben, Robert N. and McKnight, Barbara and Mellstr\"{o}m, Dan and Mitchell, Braxton D. and Mooser, Vincent and Moreno, Jose Maria and M\"{a}nnist\"{o}, Satu and O'Connell, Jeffery R. and Pascoe, Laura and Peltonen, Leena and Peral, Belen and Perola, Markus and Psaty, Bruce M. and Salomaa, Veikko and Savage, David B. and Semple, Robert K. and \v{S}kari\'{c}-Juri\'{c}, Tatjana and Sigurdsson, Gunnar and Song, Kijoung S. and Spector, Timothy D. and Syv\"{a}nen, Ann-Christine and Talmud, Philippa J. and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Uitterlinden, Andre G. and van Duijn, Cornelia M. and Vidal-Puig, Antonio and Wild, Sarah H. and Wright, Alan F. and Clegg, Deborah J. and Schadt, Eric and Wilson, James F. and Rudan, Igor and Ripatti, Samuli and Borecki, Ingrid B. and Shuldiner, Alan R. and Ingelsson, Erik and Jansson, John-Olov and Kaplan, Robert C. and Gudnason, Vilmundur and Harris, Tamara B. and Groop, Leif and Kie, Douglas P. and Rivadeneira, Fernando and Walker, Mark and Barroso, Ines and Vollenweider, Peter and Waeber, Gerard and Chambers, John C. and Kooner, Jaspal S. and Soranzo, Nicole and Hirschhorn, Joel N. and Stefansson, Kari and Wichmann, H.-Erich and Ohlsson, Claes and O'Rahilly, Stephen and Wareham, Nicholas J. and Speliotes, Elizabeth K. and Fox, Caroline S. and Laakso, Markku and Loos, Ruth J.F.}, year = {2011}, pages = {753-760}, DOI = {10.1038/ng.866}, keywords = {genome-wide association study, meta-analysis, fat distribution, adiposity, dyslipidemia, insulin resistance}, journal = {Nature genetics}, doi = {10.1038/ng.866}, volume = {43}, number = {8}, issn = {1061-4036}, title = {Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile}, keyword = {genome-wide association study, meta-analysis, fat distribution, adiposity, dyslipidemia, insulin resistance} }
@article{article, author = {Kilpel\"{a}inen, Tuomas O. and Zillikens, M. Carola and Stan\v{c}\'{a}kova, Alena and Finucane, Francis M. and Ried, Janina S. and Langenberg, Claudia and Zhang, Weihua and Beckmann, Jacques S. and Luan, Jian'an and Vandenput, Liesbeth and Styrkarsdottir, Unnur and Zhou, Yanhua and Smith, Albert Vernon and Zhao, Jing-Hua and Amin, Najaf and Vedantam, Sailaja and Shin, So Youn and Haritunians, Talin and Fu, Mao and Feitosa, Mary F. and Kumari, Meena and Halldorsson, Bjarni V. and Tikkanen, Emmi and Mangino, Massimo and Hayward, Caroline and Song, Ci and Arnold, Alice M. and Aulchenko, Yurii S. and Oostra, Ben A. and Campbell, Harry and Cupples, Adrienne L. and Davis, Kathryn E. and D\"{o}ring, Angela and Eiriksdottir, Gudny and Estrada, Karol and Fern\'{a}ndez-Real, Jose Manuel and Garcia, Melissa and Gieger, Christian and Glazer, Nicole L. and Guiducci, Candace and Hofman, Albert and Humphries, Steve E. and Isomaa, Bo and Jacobs, Leonie C. and Jula, Antti and Karasik, David and Karlsson, Magnus K. and Khaw, Kay-Tee and Kim, Lauren J. and Kivim\"{a}ki, Mika and Klopp, Norman and K\"{u}hnel, Brigitte and Kuusisto, Johanna and Liu, Yongmei and Ljunggren, Osten and Lorentzon, Mattias and Luben, Robert N. and McKnight, Barbara and Mellstr\"{o}m, Dan and Mitchell, Braxton D. and Mooser, Vincent and Moreno, Jose Maria and M\"{a}nnist\"{o}, Satu and O'Connell, Jeffery R. and Pascoe, Laura and Peltonen, Leena and Peral, Belen and Perola, Markus and Psaty, Bruce M. and Salomaa, Veikko and Savage, David B. and Semple, Robert K. and \v{S}kari\'{c}-Juri\'{c}, Tatjana and Sigurdsson, Gunnar and Song, Kijoung S. and Spector, Timothy D. and Syv\"{a}nen, Ann-Christine and Talmud, Philippa J. and Thorleifsson, Gudmar and Thorsteinsdottir, Unnur and Uitterlinden, Andre G. and van Duijn, Cornelia M. and Vidal-Puig, Antonio and Wild, Sarah H. and Wright, Alan F. and Clegg, Deborah J. and Schadt, Eric and Wilson, James F. and Rudan, Igor and Ripatti, Samuli and Borecki, Ingrid B. and Shuldiner, Alan R. and Ingelsson, Erik and Jansson, John-Olov and Kaplan, Robert C. and Gudnason, Vilmundur and Harris, Tamara B. and Groop, Leif and Kie, Douglas P. and Rivadeneira, Fernando and Walker, Mark and Barroso, Ines and Vollenweider, Peter and Waeber, Gerard and Chambers, John C. and Kooner, Jaspal S. and Soranzo, Nicole and Hirschhorn, Joel N. and Stefansson, Kari and Wichmann, H.-Erich and Ohlsson, Claes and O'Rahilly, Stephen and Wareham, Nicholas J. and Speliotes, Elizabeth K. and Fox, Caroline S. and Laakso, Markku and Loos, Ruth J.F.}, year = {2011}, pages = {753-760}, DOI = {10.1038/ng.866}, keywords = {genome-wide association study, meta-analysis, fat distribution, adiposity, dyslipidemia, insulin resistance}, journal = {Nature genetics}, doi = {10.1038/ng.866}, volume = {43}, number = {8}, issn = {1061-4036}, title = {Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile}, keyword = {genome-wide association study, meta-analysis, fat distribution, adiposity, dyslipidemia, insulin resistance} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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