Naslov
Is there relationship between metabolic syndrome (ms) and osteoporosis in diabetic type 2 patients? – experience from Croatia

Autori
Troskot, Rosana ; Marinac, Ivana ; Perić, Mato ; Stevic, Tamara ; Balić, Stjepan ; Rudan, Dijana ; Baretić, Maja.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts IOF World Congress On Osteoporosis u Osteoporosis International 19 / Kanis, John A ; Lindsay, Robert. - London : Delhi : Springer, 2008, 415-415

Skup
IOF World Congress on Osteoporosis 2008

Mjesto i datum
Bangkok, Tajland, 03.12.2008. - 07.12.2008

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
metabolic syndrome; diabetes mellitus; osteoporosis

Sažetak
AIM: To investigate influence of Metabolic Syndrome (MS) at densitometrical findings in diabetic mellitus type 2 (DM type 2) patients in traditional Mediterranean country with Mediterranean nutrition. METHODS: Investigation was performed at Internal Clinic of GH “Holy Ghost” in Zagreb: 378 diabetic patients were analyzed thereof 213 women, middle age 66.50±13.80SD and 165 men, middle age 61.39±12.58 SD. RESULTS: Sufficient criteria for MS (ATPIII-classification) existed in 308 patients (81.51%), 65 male and 243 female. Three positive components were found in 27.55%, four in 44.69% and all five components in 27.76% of patients. Analyzing the components of MS individually, it was revealed that high fasting glucose was present in 95.7%, hypertension and enlarged waist circumference existed in 87.5%, low-HDL-cholesterol in 77.91% and hypertriglyceridemia in 50.92% of patients. Elevated values of glycosyled haemoglobin(HbA1C) >6.5% were found in 2/3 of all patients. In terms of age, it was revealed that 74% of patients (87male and 192female) were over the age of 60. The distribution of densitometric results suggest that the most frequent finding in women were cases of osteoporosis (52.71%), with more than 2/3 of such cases being found within the lumbar spine region and osteopenia in 37.48%. On the other hand, osteopenia is most frequent among male participants (52.06%). Pearson's correlation coefficient has supported correlation between higher values of HbAlc (>6.4%) and densitometrical assessment of osteopenia in men within the lumbar spine region (r1=0.64 ; p<0.05), by all patients regardless gender within the same region concerning the osteoporosis (r1=0.37 ; p<0.05). Researching relation of MS and densitometrical findings, statistically significant relationship was found between MS and osteoporosis by women (p<0.0239), and by men between MS and osteopenia (p<0.037). Multiple regression analysis has established relationship between hyperglycemia and dyslipidemia with osteopenia in men (R2=0.74), and same parameters along obesity of women with osteoporosis (R2=0.59). Higher risk for osteoporotic fractures was established by females (RR=1.57). CONCLUSION: MS is associated with DM type 2. Poorly regulated glycaemia accelerates the reduction of bone mass density (BMD). On the other hand, obesity and dislypidemia can proctect the bone against fracture and increases BMD. The factors which influence the bone in DM type 2 are still unknown and require further investigations.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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