Naslov
Preskačuća translokacija koja zahvaća 11q kod neHodgkinskog limfoma.
(Jumping translocations involving 11q in a non-Hodgkin lymphoma.)

Autori
Petković, Iskra ; Konja, Josip ; Dominis, Mara ; Kaštelan, Marija ;

Izvornik
Cancer Genetics and Cytogenetics (0165-4608) 114 (1999), 2; 121-125

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, znanstveni

Ključne riječi
NeHodgkinski limfom; citogenetske analize; skačuća translokacija
(Non-Hodgkin lymphoma; cytogenetic analysis; jumping translocations)

Sažetak
This paper presents the results of a cytogenetic analysis in an 11-year-old boy with non-Hodgkin lymphoma. The investigation was performed on slides obtained from short-term culture of lymph node cells. The analyses revealed an abnormal clone with loss of Y, gain of an X chromosome, t(3 ; 22), trisomy 11, and three cytogenetically-related subclones with jumping translocations involving 11q13 as the common breakpoint region. This region is an unusual site of chromosome breakage in jumping translocations, and has not been reported thus far. Contrary to most published reports, the jumping translocation in our patient is associated with long survival.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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