Naslov
Over-represented localized sequence motifs in ribosomal protein gene promoters of basal metazoans

Autori
Perina, Dragutin ; Korolija, Marina ; Roller, Maša ; Harcet, Matija ; Jeličić, Branka ; Mikoč, Andreja ; Ćetković, Helena

Izvornik
Genomics (0888-7543) 98 (2011), 1; 56-63

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ribosomal proteins ; ribosomal protein gene promoters ; Porifera ; Cnidaria ; Placozoa.

Sažetak
Equimolecular presence of ribosomal proteins (RPs) in the cell is needed for ribosome assembly and is achieved by synchronized expression of ribosomal protein genes (RPGs) with promoters of similar strengths. Over-represented motifs of RPG promoter regions are identified as targets for specific transcription factors. Unlike RPs, those motifs are not conserved between mammals, drosophila and yeast. We analyzed RPGs proximal promoter regions of three basal metazoans with sequenced genomes: sponge, cnidarian and placozoan and found common features, such as 5’-terminal oligopyrimidine tracts and TATA-boxes. Furthermore, we identified over-represented motifs, some of which displayed the highest similarity to motifs abundant in human RPG promoters and not present in Drosophila or yeast. Our results indicate that human over-represented motifs, as well as corresponding domains of transcription factors were established very early in metazoan evolution. The fast evolving nature of RPGs regulatory network leads to formation of other, lineage specific, over-represented motifs.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA