Naslov
HFE MUTACIJE I C1/C2 POLIMORFIZAM GENA ZA TRANSFERIN U HRVATSKIH BOLESNIKA SA SHIZOFRENIJOM I SHIZOAFEKTIVNIM POREMEĆAJEM
(HFE MUTATIONS AND TRANSFERRIN C1/C2 POLYMORPHISM AMONG CROATIAN PATIENTS WITH SCHIZOPHRENIA AND SCHIZOAFFECTIVE DISORDER)

Autori
Buretić-Tomljanović, Alena ; Vraneković, Jadranka ; Rubeša, Gordana ; Jonovska, Suzana ; Tomljanović, Draško ; Šendula-Jengić, Vesna ; Kapović, Miljenko ; Ristić, Smiljana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The Seventh ISABS Conference in Forensic, Anthropologic and Medical Genetics and Mayo Clinic Lectures in Translational Medicine ; Final Program and Abstracts / Schanfield, Moses ; Primorac, Dragan ; Vuk-Pavlović, Stanimir - , 2011, 246-246

Skup
Peti hrvatski kongres iz humane genetke

Mjesto i datum
Bol, Hrvatska, 20.06.2011. - 21.06.2011

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
shizofrenija; shizoafektivni poremećaj; mutacije u genu za hemokromatozu; C1/C2 polimorfizam gena za transferin; dob prve hospitalizacije
(Schizophrenia; Schizoaffective disorder; Hemochromatosis gene mutations; Transferrin gene variant; Age at first hospital admission)

Sažetak
OBJECTIVE: To investigate the possible influence of hemochromatosis gene mutations (HFE-C282Y and H63D) and transferrin gene C2 variant (TF-C2) on susceptibility to schizophrenia and schizoaffective disorder and/or age at first hospital admission. METHODS: Genotyping was performed in 176 Croatian patients and 171 non-psychiatric Croatian controls using PCR-RFLP analyses. RESULTS: Allele and genotype distributions were not significantly different between two groups. After the age at first admission was analyzed as a continuous variable using the non-parametric Mann-Whitney U-test and Kruskal-Wallis test with negative results, the variable was dichotomized using 40 years as the cutoff. H63D-TFC2 bi-carriers were over-represented among patients in the late disease-onset group [≥ 40 years ; 7.5% vs. 25%, odds ratio (OR) = 0.243, 95% confidence interval (CI) = 0.068-0.871 ; P=0.030]. Multiple regression analysis showed no effect of combined H63D-TFC2 genotype to distribution of age at disease-onset in our sample. CONCLUSION: Investigated HFE mutations and TF-C2 variant are not high-risk genetic variants for schizophrenia/schizoaffective disorder in our population. Also, our data do not support their impact on age at onset of the first psychotic symptoms.

Izvorni jezik
Hrvatski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA