Naslov
Serial determination of magnesium and calcium in children with acute bronchoconstriction

Autori
Pavić, Ivan ; Dodig, Slavica ; Čepelak, Ivana ; Raos, Miljenko ; Zrinski Topić, Renata ; Živčić, Jadranka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXIXth Congress of the European Academy of Allergy and Clinical Immunology (EAACI ) "Asthma and rhinitis: mechanism of disease" : Abstract book / - London : Delhi : Wiley-Blackwell, 2010, 722-722

Skup
Congress of the European Academy of Allergy and Clinical Immunology 29 ; 2010)

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 05.06.2010. - 09.06.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
magnesium; calcium; salbutamol; child; bronchoconstriction

Sažetak
Many metabolic functions of magnesium and calcium are tightly interrelated: magnesium acts on bronchial smooth muscle relaxation, and calcium act as a bronchoconstrictor. The aim of this study was to find out possible changes in serum concentration of magnesium and calcium, and in asthmatic children with moderate and severe bronchoconstriction, caused by respiratory syncytial virus infection. Thirty-two children with acute bronchoconstriction were included in the study. Inhalation of salbutamol was administered according to the severity of bronchoconstriction. Moderate bronchoconstriction was confirmed in 63% children, and severe bronchoconstriction in 37% children. Magnesium and calcium concentration, as well as magnesium/calcium ratio were determined on hospital admission and the third day of short-acting aˆ 2-adrenergic receptor agonist (salbutamol) administration. Therapy with salbutamol led to a relief of dyspnea within 36 h, and symptoms of viral infection have relieved. During follow-up period, magnesium was higher in children with moderate (but not in severe) bronchoconstriction than in healthy children, with consequently higher magnesium to calcium ratio. Also, correlation between magnesium and calcium concentration was confirmed. The present study demonstrated the concentration of magnesium, to undergo changes during salbutamol administration in children with moderate bronchoobstruction caused by respiratory syncytial virus infection.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA