Naslov
Anti-cyclic citrullinated peptide and rheumatoid factor in HIV positive patients

Autori
Romić, Željko ; Derek, Lovorka ; Burek, Vitomir ; Unić, Adriana ; Serdar. Tihana ; Marijančević, Domagoj ; Morović-Vergles, Jadranka ; Mitrović, Joško ; Petrovečki, Mladen

Izvornik
Rheumatology international (0172-8172) 31 (2010), 12; 1607-1610

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
anti-cyclic citrullinated peptide ; rheumatoid

Sažetak
The aim of this study was to determine the diVerence of anti-CCP and RF between HIV positive patients and a healthy control group. The rheumatological complications in HIV positive patients are rather common and are recognized as a serious problem that requires more attention. Anti-CCP and RF are the only laboratory tools for rheumatoid disorder diagnostics and predictors of the course of the disease. We determined anti-CCP and RF in sera of 35 healthy volunteers and 45 HIV positive patients. Data were compared using chi-square test, Mann–Whitney test and ROC curve statistics. Both parameters were signiWcantly higher in HIV positive patients, and signiWcant diVerences between areas under the anti-CCP and RF curves were observed. Median value for anti-CCP in HIV positive patients was higher than the reference interval, and RF values were, in the reference interval, suggested by the manufacturer. Both anti-CCP and RF are signiWcantly higher in HIV positive patients. ROC analysis showed that anti-CCP distinguishes the two groups better than RF. Because of that, it would be of a great interest to investigate the HIV positive patients after the detailed rheumatological examination.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Farmacija

POVEZANOST RADA