Naslov
The insulin receptor INSR H1085H C>T and insulin receptor substrate 1 (IRS1) G972R polymorphisms and prostate cancer risk : a pilot study

Autori
Saračević, Andrea ; Nikolac, Nora ; Reljić, Ante ; Šimundić, Ana-Maria

Izvornik
Genetic Testing and Molecular Biomarkers (1945-0265) 15 (2011), 3; 127-131

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
prostatic neoplasms; genetic polymorphism; receptor; insulin; insulin receptor substrate proteins

Sažetak
In recent years, numerous studies have focused their attention on genes that are part of the insulin/ insulin-like growth factor 1 signaling pathway, such as the insulin receptor (INSR) and the insulin receptor substrate 1 (IRS1) genes. We aimed to examine the association of INSR H1085H C>T and IRS1 G972R polymorphisms with prostate cancer (PC). We also aimed to examine possible association with cancer severity assessed by Gleason score. We have studied 180 consecutive patients referred for PC screening. The genotyping of two polymorphisms (INSR H1085H C>T and IRS1 G972R) was performed by the polymerase chain reaction–restriction fragment length polymorphism method. There was no difference in genotype ( p=0.794) or allelic ( p=0.621) frequency of the IRS1 G972R polymorphism between PC (n=119) and control (n=61) groups. However, a significant difference was found in INSR H1085H C>T polymorphism genotype and allelic distribution. Carriers of the polymorphic allele (C/T+T/T) were more frequent in control group patients than in the PC group (54.10% vs. 37.82% ; p=0.040 ; odds ratio [95% confidence interval]=0.52 [0.28–0.96]). The IRS1 and INSR polymorphism distribution did not differ in subgroups according to Gleason score. INSR H1085H C>T polymorphism seems to be associated with PC risk, whereas IRS1 G972R is not. However, because of the limited power of this study, there is a possibility that some modest effects of the IRS1 G972R polymorphism on PC risk went undetected. Neither polymorphism is associated with the degree of PC malignancy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA