Naslov
REVIGO summarizes and visualizes long lists of Gene Ontology terms

Autori
Supek, Fran ; Bošnjak, Matko ; Škunca, Nives ; Šmuc, Tomislav

Izvornik
PLoS One (1932-6203) 6 (2011), 7; E21800-e21800

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Gene Ontology; visualization; enrichment; graph; semantic similarity; redundancy

Sažetak
Outcomes of high-throughput biological experiments are typically interpreted by statistical testing for enriched gene functional categories defined by the Gene Ontology (GO). The resulting lists of GO terms may be large and highly redundant, and thus difficult to interpret. REVIGO is a Web server that summarizes long, unintelligible lists of GO terms by finding a representative subset of the terms using a simple clustering algorithm that relies on semantic similarity measures. Furthermore, REVIGO visualizes this non-redundant GO term set in multiple ways to assist in interpretation: multidimensional scaling and graph-based visualizations accurately render the subdivisions and the semantic relationships in the data, while treemaps and tag clouds are also offered as alternative views. REVIGO is freely available at http://revigo.irb.hr/.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Računarstvo, Biotehnologija

POVEZANOST RADA