Naslov
MTHFR C667T polymorphism, folate level and hypertension in Croatian elderlies

Autori
Tomas, Željka ; Zajc Petranović , Matea ; Krajačić , Petra ; Škarić-Jurić , Tatjana ; Miličić , Jasna ; Tomek-Roksandić , Spomenka ; Smolej Narančić , Nina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Human Genetics (Vol.19, Suppl. 2) / - : Nature publishing group, 2011, 341-341

Skup
European Human Genetics Conference 2011

Mjesto i datum
Amsterdam, Nizozemska, 28.05.2011. - 31.05.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MTHFR ; folate ; longevity

Sažetak
The Methylenetetrahydrofolate reductase (MTHFR) enzyme is involved in reducing homocysteine level which, when elevated, has been found to predict cardiovascular events. Adequate blood folate status may decrease the circulating level of homocysteine and lower the incidence of cardiovascular diseases (CVD). We studied MTHFR gene variant C667T, its association with hypertension (HT) and CVD endpoints in Croatian elderly population (85-101 yrs ; mean=88.23 yrs ; N=303 ; 65.3% hypertensives). Compared to the previously reported data, the TT genotype frequency was twice as high in senescents as in Croatian general population (12.5% vs. 6%, p=0.023). The results of multiple logistic analysis in elderlies showed significance of younger age (<90 yrs) and TT genotype (OR 2.175, p=0.039) in predicting HT. T allele carriers had increased incidence of stroke in comparison to non-carriers (p=0.027). Further, we evaluated associations between MTHFR genotype, serum folate and HT. Regardless of association of low folate (<7 pmol/l) and TT genotype (p=0.002), we found no association of folate and HT. According to our results, adequate folate levels in blood serum have no protective effect on incidence of HT. Therefore, we suggest that further research of folates - CVD endpoints relation should be directed towards broader spectrum of genes involved in folate and homocysteine metabolism rather than focusing on MTHFR polymorphisms as the main factor. Also, our results indicate that T allele may have some selective advantage that contributes to longevity.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Javno zdravstvo i zdravstvena zaštita, Etnologija i antropologija

POVEZANOST RADA