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Pregled bibliografske jedinice broj: 512329

Protein-DNA Interactions Determine the Shapes of DNA Toroids Condensed in Virus Capsids

Leforestier, Amelie; Šiber, Antonio; Livolant, Francoise; Podgornik, Rudolf
Protein-DNA Interactions Determine the Shapes of DNA Toroids Condensed in Virus Capsids // Biophysical journal, 100 (2011), 9; 2209-2216 doi:10.1016/j.bpj.2011.03.012 (međunarodna recenzija, članak, znanstveni)

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Naslov
Protein-DNA Interactions Determine the Shapes of DNA Toroids Condensed in Virus Capsids

Autori
Leforestier, Amelie ; Šiber, Antonio ; Livolant, Francoise ; Podgornik, Rudolf

Izvornik
Biophysical journal (0006-3495) 100 (2011), 9; 2209-2216

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
protein; DNA; virus; counterions; PEG; condensation; toroid; elasticity

Sažetak
DNA toroids that form inside the bacteriophage capsid present different shapes according to whether they are formed by the addition of spermine or polyethylene glycol to the bathing solution. Spermine-DNA toroids present a convex, faceted section with no or minor distortions of the DNA interstrand spacing with respect to those observed in the bulk, whereas polyethylene glycol-induced toroids are flattened to the capsid inner surface and show a crescent-like, nonconvex shape. By modeling the energetics of theDNA toroid using a free-energy functional composed of energy contributions related to the elasticity of the wound DNA, exposed surfaceDNAenergy, and adhesion between theDNAand the capsid, we established that the crescent shape of the toroidal DNA section comes from attractive interactions between DNA and the capsid. Such attractive interactions seem to be specific to the PEG condensation process and are not observed in the case of spermine-induced DNA condensation.

Izvorni jezik
Engleski

Znanstvena područja
Fizika



POVEZANOST RADA

Projekti:
035-0352828-2837 - Energetskom kompeticijom uvjetovani oblici i strukture nanometarskih sustava (Šiber, Antonio, MZOS ) ( CroRIS)

Ustanove:
Institut za fiziku, Zagreb

Profili:

Avatar Url Antonio Šiber (autor)

Poveznice na cjeloviti tekst rada:

doi www.cell.com

Citiraj ovu publikaciju:

Leforestier, Amelie; Šiber, Antonio; Livolant, Francoise; Podgornik, Rudolf
Protein-DNA Interactions Determine the Shapes of DNA Toroids Condensed in Virus Capsids // Biophysical journal, 100 (2011), 9; 2209-2216 doi:10.1016/j.bpj.2011.03.012 (međunarodna recenzija, članak, znanstveni)
Leforestier, A., Šiber, A., Livolant, F. & Podgornik, R. (2011) Protein-DNA Interactions Determine the Shapes of DNA Toroids Condensed in Virus Capsids. Biophysical journal, 100 (9), 2209-2216 doi:10.1016/j.bpj.2011.03.012.
@article{article, author = {Leforestier, Amelie and \v{S}iber, Antonio and Livolant, Francoise and Podgornik, Rudolf}, year = {2011}, pages = {2209-2216}, DOI = {10.1016/j.bpj.2011.03.012}, keywords = {protein, DNA, virus, counterions, PEG, condensation, toroid, elasticity}, journal = {Biophysical journal}, doi = {10.1016/j.bpj.2011.03.012}, volume = {100}, number = {9}, issn = {0006-3495}, title = {Protein-DNA Interactions Determine the Shapes of DNA Toroids Condensed in Virus Capsids}, keyword = {protein, DNA, virus, counterions, PEG, condensation, toroid, elasticity} }
@article{article, author = {Leforestier, Amelie and \v{S}iber, Antonio and Livolant, Francoise and Podgornik, Rudolf}, year = {2011}, pages = {2209-2216}, DOI = {10.1016/j.bpj.2011.03.012}, keywords = {protein, DNA, virus, counterions, PEG, condensation, toroid, elasticity}, journal = {Biophysical journal}, doi = {10.1016/j.bpj.2011.03.012}, volume = {100}, number = {9}, issn = {0006-3495}, title = {Protein-DNA Interactions Determine the Shapes of DNA Toroids Condensed in Virus Capsids}, keyword = {protein, DNA, virus, counterions, PEG, condensation, toroid, elasticity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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