Naslov
Relationship between albuminuria and thyroid function in euthyroid patients with type 1 diabetes mellitus

Autori
Bulum, Tomislav ; Smirčić-Duvnjak, Lea ; Car, Nikica ; Prkačin, Ingrid

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
World Congress of Nephrology Book of Abstracts, 2011. SA179 / - , 2011

Skup
World Congress of Nephrology

Mjesto i datum
Vancouver, Kanada, 08.04.2011. - 12.04.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
albuminuria; thyroid; type 1 diabetes

Sažetak
In this study of a large cohort of patients with type 1 diabetes we provided the evidence that albuminuria in euthyroid patients with type 1 diabetes, with normal serum creatinine levels and creatinine clearance, was associated with decreased serum thyroid hormone and especially TSH levels. The decreased thyroid function in patients with non-thyroidal diseases like chronic kidney disease is referred to as the euthyroid sick syndrome. Thyrotropin secretion is decreased, which causes decreased thyroidal secretion of fT3 and decreased availability of T4 for peripheral conversion to T3. The decrease in TSH secretion, despite lower levels of circulating thyroid hormone, explains the euthyroid sick syndrome as a host's defense mechanism against protein wasting. We showed that these abnormalities already occurring in patients with albuminuria who had normal thyroid status, serum creatinine and creatinine clearance.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA