Pregled bibliografske jedinice broj: 51072
Neurotrophic role of interleukin-6 and soluble interleukin-6 receptors in N1E-115 neuroblastoma cells
Neurotrophic role of interleukin-6 and soluble interleukin-6 receptors in N1E-115 neuroblastoma cells // Journal of Neuroimmunology., 102 (2000), 1; 8-16 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 51072 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Neurotrophic role of interleukin-6 and soluble interleukin-6 receptors in
N1E-115 neuroblastoma cells
Autori
Knežević-Ćuća, Jadranka ; Stansberry, KB ; Johnston, G ; Zhang, J ; Keller ET ; Vinik AI.
Izvornik
Journal of Neuroimmunology. (0165-5728) 102
(2000), 1;
8-16
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Il-6. Il-6 receptor. Neuroblastoma. Neurotrophic. In vitro. Neuropathy.
Sažetak
Interleukin 6 (IL-6) plays a role in physiological and pathophysiological processes in neuronal cells. We studied whether IL-6 plays a role in neuroblastoma cells in culture. These studies demonstrate that N1E-115 cells constitutively express IL-6 but not IL-6R. Exogenous IL-6 stimulated neuronal proliferation in a dose-dependent manner. Under serum-free conditions soluble IL-6 receptors (sIL-6R) alone or in combination with IL-6 exerted significant proliferative effects, while IL-6 alone failed to promote cell proliferation. Neutralizing anti-IL-6 antibody caused a 30-40% reduction in IL-6 mediated proliferation. Our results suggest the importance of IL-6/sIL-6R for proliferation and survival of N1E-115 adrenergic neuroblastoma cells.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
045001
Ustanove:
Klinika za dijabetes, endokrinologiju i bolesti metabolizma Vuk Vrhovac
Profili:
Jadranka Knežević-Ćuća
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
