Naslov
Involuntary emotional expression disorder in dementia

Autori
Mimica, Ninoslav ; Presečki, Paola ; Mimica, Nevenka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Neurologia Croatica 55 (Suppl 4) - Book of Abstracts - 3rd Croatian congress on Alzhemier's disease with international participation / Šimić, Goran ; Mimica, Ninoslav - Zagreb : Denona, 2006, 47-47

Skup
3rd Croatian congress on Alzhemier's disease with international participation

Mjesto i datum
Brijuni, Hrvatska, 07.09.2006. - 10.09.2006

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
involuntary emotional expression disorder (IEED) ; dementia

Sažetak
Involuntary emotional expression disorder (IEED) is proposed to describe a syndrome of relatively stereotypical episodes of uncontrollable crying and/or laughing, resulting from lesions of multiple types, in multiple brain regions. Episodes may be incongruent with mood or congruent with mood, but exces¬sive. A number of patients suffer from this unique syndrome, including indi¬viduals who have suffered a stroke or traumatic brain injuri (TBI) as well as patients with amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), dementias such as Alzheimer's disease, and motor disorders such as Parkinson's disease. This suggest a common emotional neurobiological sub¬strate for IEED (frontal - subcortical - cerebellar networks), disrupted in the diseases in which IEED occurs. IEED is underrecognized by clinicians, misdi¬agnosed and undertreated. Distinguishing IEED from mood disorders and other behavioral distur¬bances is imperative given that the treatments for these conditions are not identical. Rating scales can assist in quantifying the severity of IEED, but are not used in diagnosis.They should be applied after the presence of the syn¬drome has been estabilished using the draft criteria.There are at least 2 scales that may be of use toward this end: the Pathological Laughter and Crying Scale (PLACS) and the Center for Neurologic Study - Lability Scale (CNS-LS). Pharmacological treatment can reduce symptoms and improve quality of life for the patient. Small-scale studies suggest that tricyclics (TCAs) and selective serotonin uptake inhibitors (SSRIs) may improve IEED symptoms. Two large, double blind studies have shown that dextromethorphan (DM) and quinidine (Q) is an effective treatment for IEED. No evidence for benefit of nonpharmacological approaches on number of crying/laughing episodes.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Indexed/Abstracted in: Neuroscience Citation Index ;
EMBASE/Excerpta Medica

POVEZANOST RADA