Naslov
Impact of early steroid withdrawal (ESW) on progression of chronic biopsy scores after kidney transplantation

Autori
Mihovilović, Karlo ; Bacalja, Jasna ; Galešić Ljubanović, Danica ; Kovačević-Vojtušek, Ivana ; Gracin, Sonja ; Gustin, Denis ; Vidas, Željko ; Sabljar-Matovinović, Mirjana ; Knotek, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Nationa Kidney Foundation (NKF) 2011 Spring Clinical Meetings Abstracts ; u American journal of kidney diseases 57 (2011) (4) B1-B108 / - , 2011, B68-B68

Skup
Nationa Kidney Foundation 2011 Spring Clinical Meetings

Mjesto i datum
Las Vegas (NV), Sjedinjene Američke Države, 26.04.2011. - 01.05.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
early steroid withdrawal; chronic scores; kidney transplantation

Sažetak
Long-term effects of ESW on development of chronic pathohistology changes in kidney allograft is unclear. In this study we compared chronic scores on protocol biopsies in Caucasian kidney recipients(N=41) without DGF with ESW vs. continuous steroids on top of CNI and MMF. Induction consisted of IL-2RA or ATG. Protocol biopsies were done on day 0 and 1 year afer transplant. Chronic scores (ci, ct, cg, mm, cv and ah) were analyzed by Banff' 97 classification. ESW was not associated with changes in ci, ct, cg, mm and cv scores, but slight progression of ah score was noticed in ESW group(0.49±0.51 vs. 0.21±0.41 ; p=0.02). In multivariate analysis including recipient age and gender, donor age, type of donation (living or deceased) and type of transplant (kidney or kidney/pancreas), ESW was independently associated with progression of ah score (p=0.049). In conclusion, ESW may cause progression of ah score during first 12 months postransplant, without impact on other chronic scores.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Doi:10.1053/j.ajkd.2011.02.209

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