Naslov
High salt diet is associated with impaired microvascular reactivity in young healthy female human subjects

Autori
Grizelj, Ivana ; Čavka, Ana ; Jelaković, Bojan ; Lombard, Julian H. ; Mihaljević, Ivan ; Koller, Akos ; Drenjančević, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biopolymers and Cell / El'Skaya, Anna V. - Kijev, 2011, 76-76

Skup
RECOOP HST, Bridges in Life Science, 6th Annual Scientific Meeting

Mjesto i datum
Bratislava, Slovačka, 08.10.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Hypertension; High-salt diet; Microcirculation; Laser Doppler flowmetry

Sažetak
Studies on experimental animals have shown that changes in salt intake significantly alter vascular reactivity to different physiological stimuli, in conduit vessels, resistance arteries, and in the microcirculation. However, the effects of high salt (HS) intake on microvascular endothelial response in young healthy human subjects without pre-existing conditions such as diabetes and hypertension are still unknown. The aim of this study was to assess effects of acute salt loading on microvascular reactivity during reactive hyperemia in young healthy women, using non-invasive Laser Doppler Flowmetry (LDF). Eleven normotensive women (21±3 years) were instructed to maintain a low-salt (LS) diet (less than 40 mmol Na/daily) during 7 days. Simultaneously they were divided into HS group (N=6) (intake of 200 mmol Na/daily) and placebo group (N=5). LDF was performed before and after salt diet protocol as measurement of relative changes in blood flow between baseline flow and reperfusion that follows 1- and 2-minute occlusion. Blood sampling for plasma electrolytes, aldosterone and plasma renin activity, just as 24-hour urine sodium and potassium excretion took place before and after diet protocol. In the HS group there was a statistically significant decrease in microvascular reactivity after 1-minute occlusion (endothelium-dependant mechanisms) with no difference after a 2-minute occlusion (maximum dilation ability), before and after HS diet. The increased urinary volume, decreased urinary sodium, and increased urinary potassium concentration in subjects on LS diet, and increased urinary sodium concentration in subjects on HS diet confirmed consistency of experimental protocol and subjects’ adherence to diet. Although plasma renin activity and serum aldosterone concentration decreased in HS diet and increased in women on LS diet, they didn’t reach statistical significance. This study shows that even one week of HS intake may have negative effect on microvascular reactivity, decreasing blood flow during reactive hyperemia by affecting endothelial function. Increased number of subjects in further study is needed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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