Pregled bibliografske jedinice broj: 509136
Tumor suppressor gene Axin 1.Atlas Genet Cytogenet Oncol Haematol. May 2011
Tumor suppressor gene Axin 1.Atlas Genet Cytogenet Oncol Haematol. May 2011 // Atlas of Genetics and Cytogenetics in Oncology and Haematology, May 2011 (2011), 7-11 (podatak o recenziji nije dostupan, pregledni rad, znanstveni)
CROSBI ID: 509136 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Tumor suppressor gene Axin 1.Atlas Genet Cytogenet Oncol Haematol. May 2011
Autori
Pećina-Šlaus, Nives ; Nikuševa Martić, Tamara ; Kokotović, Tomislav
Izvornik
Atlas of Genetics and Cytogenetics in Oncology and Haematology (1768-3262) May 2011
(2011);
7-11
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
AXIN-1; AXIN; hAXIN; MGC52315; Axis inhibitor 1
Sažetak
Tumor suppressor gene Axin 1 is an inhibitor of the Wnt signaling pathway. It down-regulates beta-catenin, wnt pathway's main effector signaling molecule, by facilitating its phosphorylation by GSK3-beta. It binds directly to APC (adenomatous polyposis coli), beta-catenin, GSK3-beta and dishevelled forming a so called “beta-catenin destruction complex” in which phosphorylated beta-catenin is targeted for quick ubiquitinilation and degradation in the 26S proteosome. In response to wnt signaling, or under the circumstances of mutated axin or APC, beta-catenin is stabilized, accumulates in the cytoplasm and enters the nucleus, where it finds a partner, a member of the DNA binding protein family LEF/TCF. Together they stimulate the expression of target genes including c-myc, c-jun, fra-1 and cyclin D1.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
108-1081870-1905 - Uloga signalnog puta wnt u tumorigenezi i embriogenezi mozga (Pećina-Šlaus, Nives, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
Citiraj ovu publikaciju:
Uključenost u ostale bibliografske baze podataka::
- The Atlas is indexed by the Current Web Contents, and hyperlinked by HUGO, the WHO , International Union Against Cancer
