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Pregled bibliografske jedinice broj: 508267

Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: Synthesis, antiproliferative activity and DNA binding studies

Hranjec, Marijana; Lučić, Borka; Ratkaj, Ivana; Kraljević Pavelić, Sandra; Piantanida, Ivo; Pavelić, Krešimir; Karminski-Zamola, Grace
Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: Synthesis, antiproliferative activity and DNA binding studies // European journal of medicinal chemistry, 46 (2011), 7; 2748-2758 doi:10.1016/j.ejmech.2011.03.062 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 508267 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: Synthesis, antiproliferative activity and DNA binding studies

Autori
Hranjec, Marijana ; Lučić, Borka ; Ratkaj, Ivana ; Kraljević Pavelić, Sandra ; Piantanida, Ivo ; Pavelić, Krešimir ; Karminski-Zamola, Grace

Izvornik
European journal of medicinal chemistry (0223-5234) 46 (2011), 7; 2748-2758

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
imidazo[4 ; 5-b]pyridines ; triaza-benzo[c]fluorenes ; antiproliferative activity ; interaction with ctDNA ; apoptosis ; cell cycle

Sažetak
In the present paper, we have described the synthesis and biological activity of the novel derivatives of imidazo[4, 5-b]pyridines and triaza-benzo[c]fluorenes (7-21, 24-26, 28-29). A preponderance of these compounds exerted strong cytostatic effects on the panel of seven human tumour cell lines in a dose-dependent manner. In particular, imidazo[4, 5-b]pyridines and triaza-benzo[c]fluorenes including 2-imidazolinyl derivatives showed the most potent antitumour activity. Similarly, triaza-benzo[c]fluorenes 18 and 20 induced strong growth inhibition of tested tumour cell lines, and showed low cytotoxicity in normal human fibroblasts. DNA interaction studies of these compounds demonstrated that N-methylated 16 and 2-imidazolinyl 28 triaza-benzo[c]fluorenes bind to DNA in an intercalative mode.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
MZOS-098-0982914-2918 - Dizajn, sinteza i ispitivanje interakcija malih molekula s DNA, RNA i proteinima (Piantanida, Ivo, MZOS ) ( CroRIS)
MZOS-125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni (pametni) lijekovi (Hranjec, Marijana, MZOS ) ( CroRIS)
MZOS-335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Peter-Katalinić, Jasna, MZOS ) ( CroRIS)
098-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Profili:

Avatar Url Marijana Hranjec (autor)

Avatar Url Krešimir Pavelić (autor)

Avatar Url Ivo Piantanida (autor)

Avatar Url Sandra Kraljević Pavelić (autor)

Avatar Url Ivana Ratkaj (autor)

Avatar Url Grace Karminski-Zamola (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com dx.doi.org

Citiraj ovu publikaciju:

Hranjec, Marijana; Lučić, Borka; Ratkaj, Ivana; Kraljević Pavelić, Sandra; Piantanida, Ivo; Pavelić, Krešimir; Karminski-Zamola, Grace
Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: Synthesis, antiproliferative activity and DNA binding studies // European journal of medicinal chemistry, 46 (2011), 7; 2748-2758 doi:10.1016/j.ejmech.2011.03.062 (međunarodna recenzija, članak, znanstveni)
Hranjec, M., Lučić, B., Ratkaj, I., Kraljević Pavelić, S., Piantanida, I., Pavelić, K. & Karminski-Zamola, G. (2011) Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: Synthesis, antiproliferative activity and DNA binding studies. European journal of medicinal chemistry, 46 (7), 2748-2758 doi:10.1016/j.ejmech.2011.03.062.
@article{article, author = {Hranjec, Marijana and Lu\v{c}i\'{c}, Borka and Ratkaj, Ivana and Kraljevi\'{c} Paveli\'{c}, Sandra and Piantanida, Ivo and Paveli\'{c}, Kre\v{s}imir and Karminski-Zamola, Grace}, year = {2011}, pages = {2748-2758}, DOI = {10.1016/j.ejmech.2011.03.062}, keywords = {imidazo[4, 5-b]pyridines, triaza-benzo[c]fluorenes, antiproliferative activity, interaction with ctDNA, apoptosis, cell cycle}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2011.03.062}, volume = {46}, number = {7}, issn = {0223-5234}, title = {Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: Synthesis, antiproliferative activity and DNA binding studies}, keyword = {imidazo[4, 5-b]pyridines, triaza-benzo[c]fluorenes, antiproliferative activity, interaction with ctDNA, apoptosis, cell cycle} }
@article{article, author = {Hranjec, Marijana and Lu\v{c}i\'{c}, Borka and Ratkaj, Ivana and Kraljevi\'{c} Paveli\'{c}, Sandra and Piantanida, Ivo and Paveli\'{c}, Kre\v{s}imir and Karminski-Zamola, Grace}, year = {2011}, pages = {2748-2758}, DOI = {10.1016/j.ejmech.2011.03.062}, keywords = {imidazo[4, 5-b]pyridines, triaza-benzo[c]fluorenes, antiproliferative activity, interaction with ctDNA, apoptosis, cell cycle}, journal = {European journal of medicinal chemistry}, doi = {10.1016/j.ejmech.2011.03.062}, volume = {46}, number = {7}, issn = {0223-5234}, title = {Novel imidazo[4,5-b]pyridine and triaza-benzo[c]fluorene derivatives: Synthesis, antiproliferative activity and DNA binding studies}, keyword = {imidazo[4, 5-b]pyridines, triaza-benzo[c]fluorenes, antiproliferative activity, interaction with ctDNA, apoptosis, cell cycle} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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  • CA Search (Chemical Abstracts)

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