Naslov
MALIGNANT CEREBELLAR TUMORS OF THE YOUTH

Autori
Boban, Marko ; Brinar, Marko ; Jednacak, Hrvoje

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, ostalo

Izvornik
Abstract book / - Zagreb, 2005, 32-32

Skup
1st. CROSS (CROatian Student Summit)

Mjesto i datum
Zagreb, Hrvatska, 17.03.2005. - 21.03.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
glioma; medulloblastoma; high grade glioma; operation; disease free survival

Sažetak
INTRODUCTION: Medulloblastoma (as an entity) is the most common malignant brain tumor of the youth, WHO classification grade IV. Modern multidisciplinary approach has changed overall poor prognosis of the disease. Overall 5 years from diagnose survival rate increased from 20 % in 1960s to 50-80% nowadays. This is due to improvements in neuro-imaging radiology, neurosurgical techniques, increased doses of radiation (this solitary changed ultimate death from the disease to 50 % survival) and more advances in adding (poly)chemotherapy to standard treatment protocol. Surgery is the first phase that for the most part regulates outcome of the disease. PATIENTS AND METHODS: Patients with the diagnosis of „medulloblastoma“or „tumor fosse cranii posterior“(infratentorial tumor) were formed from hospital's registry of operations, for the period 01.Jan.1999. – 31.Dec.2004. Based on the patohystological data we ruled out patients that had other tumors (non-medulloblastoma). We reviewed diagnostic, clinical, pathological, neurosurgical and oncological personal patients’ histories from co-working departments and presented data relevant for the course and outcome of the disease. RESULTS: We present 34 patients, 24 (70, 58%) male and 10 (29, 42%) female categorised based on the results of neurosurgical and oncological management. In 15 patients (44, 11%) with gross total resection, and oncological treatment disease progression free survival rate was achieved in 13 patients (86, 66%) during this study. In 19 (55, 88%) patients with partial removal of tumor and after oncological treatment 12 patients achieved disease progression free survival rate (63, 15%). Patients with 3 years of age or less, made up a special group because of clinical properties, with 6 patients (17, 65%) of which 3 (50%) died. Chemotherapy was administered in 34 patients (100%) and 26 (76, 47%) patients received both irradiation and chemotherapy. 31 patients presented with symptoms of raised intracranial pressure combined with cerebellar symtomatology of which 8 patients needed postoperative VP drainage. Postoperative complications were: meningitis in 5 patients, liquorrhea in 8 patients and major neurological deficit in 15 patients of which 11 were transient while in 4 patients persisted. There were 8 reoperations performed due to relapse of the tumorous disease. CONCLUSION: Big improvement in treatment and prognosis of the disease was made in the last ten years. Basic outcome is due to child's age at diagnoses with poor survival rates in group with 3 years of age or less because they do not recieve irradiation. Earlier clinical diagnosis, patohystological and clinical grade of the disease greatly influences the outcome rates. Tumor placed in vital parts of the brain is allso important handicep in overall prognosis. It becomes neurosurgical subtotally manageable and leaves tumorous sprouts along with neural deficit. We feel that by improving coordination among team members we can further improve short – term results. Yet, more time is needed to assess effects of modern medicine on long – term prognosis, so further studies are needed.

Izvorni jezik
Engleski

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