Pregled bibliografske jedinice broj: 506843
NMR studies of human prion proteins with inherited mutations
NMR studies of human prion proteins with inherited mutations // 4th SISSA/ELETTRA PRION research workshop
Trst, 2011. str. 4-4 (predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 506843 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
NMR studies of human prion proteins with inherited mutations
Autori
Biljan, Ivana ; Ilc, Gregor ; Giachin, Gabriele ; Legname, Giuseppe ; Plavec, Janez
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
4th SISSA/ELETTRA PRION research workshop
/ - Trst, 2011, 4-4
Skup
4th SISSA/ELETTRA PRION research workshop
Mjesto i datum
Trst, Italija, 10.01.2011
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
NMR; human prion protein; prion diseases; mutations
Sažetak
Prion diseases are fatal neurodegenerative disorders caused by an aberrant accumulation of the misfolded cellular prion protein (PrPC) conformer, denoted as infectious scrapie isoform or PrPSc. Our understanding of the mechanisms by which mutations cause disease remains limited. In this work results of recent high-resolution NMR structural studies on human prion protein variants carrying pathological mutations are presented.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
