Prognostic value of connexin43 expression in patients with clinically localized prostate cancer

Benko, Goran; Spajić, Borislav; Demirović, Alma; Štimac, Goran; Krušlin Božo; Tomas, Davor

doi:10.1038/pcan.2010.51

Pregled bibliografske jedinice broj: 506117

Prognostic value of connexin43 expression in patients with clinically localized prostate cancer

Benko, Goran; Spajić, Borislav; Demirović, Alma; Štimac, Goran; Krušlin Božo; Tomas, Davor

Prognostic value of connexin43 expression in patients with clinically localized prostate cancer // Prostate cancer and prostatic diseases, 14 (2011), 1; 90-95 doi:10.1038/pcan.2010.51 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 506117 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Prognostic value of connexin43 expression in patients with clinically localized prostate cancer

Autori
Benko, Goran ; Spajić, Borislav ; Demirović, Alma ; Štimac, Goran ; Krušlin Božo ; Tomas, Davor

Izvornik
Prostate cancer and prostatic diseases (1365-7852) 14 (2011), 1; 90-95

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
connexin43; prognosis

Sažetak
Connexins (Cxs) are a family of transmembrane proteins that build cell-to-cell channels in gap junctions. Gap junctions composed of Cxs have an essential role in intercellular communication, adhesion and cell differentiation. Several studies investigated the role of connexin43 (Cx43) in different carcinomas ; however, none investigated its prognostic role in prostate cancer. Cx43 expression and relationship with established prognostic features were assessed in a cohort of 102 patients treated with radical prostatectomy for clinically localized prostate adenocarcinoma. Cx43 expression in prostate cancer was significantly associated with established features indicative of worse prognosis, such as follow-up time (P < 0.001) and preoperative PSA (P < 0.007). Patients with lower Cx43 expressions in tumours have shorter follow-up time, which indicated shorter disease-free survival and higher preoperative PSA values. Furthermore, tumours with positive surgical margins (P < 0.001) showed significantly lower Cx43 expression compared with tumours without this feature. In univariate (P < 0.001) and multivariate (P = 0.014) analyses, decreased Cx43 expression was found to be a significant predictor of biochemical recurrence free-survival. Study results show the association of decreased Cx43 expression with prostate cancer progression. Moreover, Cx43 could serve as an additional prognostic marker and used together with traditional prognostic markers might help in further stratifying the risk of disease progression in patients with prostate cancer.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
108-1081870-1884 - Razvojna neuropatologija genetskih malformacija moždane kore čovjeka (Krušlin, Božo, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Opća bolnica Varaždin

Profili:

Borislav Spajić (autor)