Naslov
Agitation in acute episode schizophrenia : carbamazepine treatment in combination with haloperidol vs. combined neuroleptics

Autori
Makarić, Gordan ; Folnegović-Šmalc, Vera ; Folnegović, Zdenko ; Mimica, Ninoslav

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 10th Biennial Winter Workshop on Schizophrenia. U: Schizophrenia Research 41 (2000), (1) / - , 2000, 210-210

Skup
Biennial Winter Workshop on Schizophrenia

Mjesto i datum
Davos, Švicarska, 05.02.2000. - 11.02.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
agitation in schizophrenia ; haloperidol ; carbamazepine ; promazine

Sažetak
Objectives are shor– term comparison of two therapeutic strategies and measurement of he agitation. 12 male and 14 female agitated schizophrenics (DSM IV) admitted to intensive care ward. They were assessed during 7 days (1, 3, 5, 7 day) with PANSS – excited items for agitation (4, 7, 18, 22, 28). Agitation – Calmness Evaluation Scale (ACES), Clinical Global Impression (CGI) and UKU Side Effect Rating Scale. Inclusion criteria were at least moderate score on used scales and stabille physical condition. The patients were divided in two groups without significant differences between them according to sex, age and score level. There were two therapeutic strategies used: (1) combination of haloperidol (10-20 mg/day) and promazine (100-600 mg/day) or levomepromezine (50 – 400mg/day). (2) Combination of haloperidol (10-20 mg/day) and carbamazepine (200mg 1st day, stepping 200mg each day till 1200mg/day). Clinically significant improvement on PANSS- excited items, ACES and CGI were shown in the group 2 after day 3, and in group 1 after day 5. Side effects were significantly less in group 2. The application of carbamazepine with haloperidol showed faster result and less side – effects. Use of these combination seems to be rational advantage in treatment of agitated schizophrenics.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA