Naslov
Pharmacokinetics of an immunomodulating dose of levamisole in weaned pigs

Autori
Šuran, Jelena ; Flajs, Dubravka ; Peraica, Maja ; Prevendar-Crnić, Andreja ; Šperanda, Marcela ; Božić, Frane

Izvornik
Acta veterinaria Hungarica (0236-6290) 61 (2013), 3; 376-382

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Levamisole; Pharmacokinetics; Immunomodulating dose; Weaned pigs

Sažetak
The pharmacokinetics (PK) of an immunomodulating dose of levamisole was studied in 20 weaned crossbred pigs divided in two treatment groups. In this parallel-design study, a single dose of levamisole (2.5 mg/kg b.w.) was administered by intramuscular (i.m.) or oral (p.o.) route. Blood samples were collected at predetermined time intervals before and after drug administration. Using compartmental analysis, levamisole followed two-compartmental open model. In the PK analysis of levamisole disposition, the elimination half-life (t1/2β) was 2.549 ± 1.311 and 3.168 ± 0.897 h for the i.m. and p.o. routes, respectively. Mean peak serum concentration (Cmax) was 0.473 ± 0.171 and 0.207 ± 0.070 µg/mL for the i.m. and p.o. routes, respectively. The time to reach Cmax (tmax) was 0.700 ± 0.349 and 0.950 ± 0.369 h for the i.m. and p.o. routes, respectively. Statistically significant differences between i.m. and p.o. routes in both intercepts, apsorption half-time (t1/2α), Cmax, area under the plasma concentration-time curve from time zero to infinity (AUC0-inf), area under the plasma concentration–time curve from time 0 to the last quantifiable time point (AUC0-t) and area under the plasma concentration-time curve calculated from exponential terms (AUCexpo) were determined. All values except t1/2α were significantly higher after i.m. administration. Further research is needed to establish a relationship between the PK and immunomodulating effect of levamisole in pigs.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

POVEZANOST RADA