Pregled bibliografske jedinice broj: 505008
Synthetic routes to cationic isothiocyanato diphenyl and tetraphenyl porphyrins, and their conjugation to monoclonal antibodies for use in photodynamic therapy
Synthetic routes to cationic isothiocyanato diphenyl and tetraphenyl porphyrins, and their conjugation to monoclonal antibodies for use in photodynamic therapy // Tetrapyrrole Discussion Group Meeting (TPDG Meetings)
Kingston upon Hull, Ujedinjeno Kraljevstvo, 2005. (poster, međunarodna recenzija, neobjavljeni rad, znanstveni)
CROSBI ID: 505008 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthetic routes to cationic isothiocyanato diphenyl and tetraphenyl porphyrins, and their conjugation to monoclonal antibodies for use in photodynamic therapy
Autori
Peša, Nela ; Smith, Karen A. ; Savoie, Huguette ; Greenman, John ; Boyle, Ross W.
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni
Skup
Tetrapyrrole Discussion Group Meeting (TPDG Meetings)
Mjesto i datum
Kingston upon Hull, Ujedinjeno Kraljevstvo, 30.06.2005. - 01.07.2005
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Porphyrin synthesis; Monoclonal antibody; Bioconjugation; Photodynamic therapy
Sažetak
Successful synthetic routes to cationic isothiocyanato diphenyl and tetraphenyl porphyrins are described. The potential of these compounds as targeted photosensitisers for use in photodynamic therapy(PDT) is demonstrated by their efficient conjugation to monoclonal antibodies and the ability of the bioconjugates to bind and photodynamically inactivate cancer cells that express the corresponding antigen.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti
