Pregled bibliografske jedinice broj: 504352
Telomeres control cell aging
Telomeres control cell aging // Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, 35 (2010), 508; 69-75 (podatak o recenziji nije dostupan, pregledni rad, znanstveni)
CROSBI ID: 504352 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Telomeres control cell aging
Autori
Rubelj, Ivica
Izvornik
Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti (1330-5301) 35
(2010), 508;
69-75
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni
Ključne riječi
telomeres ; cell senescence ; aging
Sažetak
It has been well established that various mammalian cells demonstrate a limited growth capacity in culture referred to as cellular or replicative senescence. There is also some evidence in support of the idea that this is the basis for organismal aging. Recent studies have revealed the molecular mechanisms of telomere involvement in cell senescence, cell cycle control, genome (in)stability and immortalization. This has provided an explanation of various phenomena related to process of aging and carcinogenesis. In this review I aim to describe some of the most important features of normal cell aging and phenomena that result in malignant transformation.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
POVEZANOST RADA
Projekti:
098-0982913-2768 - Struktura i funkcija telomera u kontroli staničnog rasta (Rubelj, Ivica, MZOS ) ( CroRIS)
Ustanove:
Institut "Ruđer Bošković", Zagreb
Profili:
Ivica Rubelj
(autor)
