Naslov
Impact of metronidazole primary resistance on H. Pylori eradication

Autori
Prskalo, Marija ; Katičić, Miroslava ; Šabarić, Branka ; Tićak, Mirjana ; Cvrlje-Čolić, Vesna ; Papa, Branko ; Kalenić, Smilja ; Plečko, Vanda ; Dominis, Mara ; Škurla, Bruno ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Gut 1999;45(Suppl V) / Farthing, J, G, Michael ; - London : Delhi : British Medicaj Journal, 1999

Skup
7th United European Gastroenterology Week

Mjesto i datum
Rim, Italija, 25.11.1999. - 30.11.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori; therapy; metronidazole; resistance; eradication
(Helicobacter pylori; terapija; metronidazol; rezistencija; eradikacija)

Sažetak
Background: In the quest for better anti-H. Pylori therapy the effect of antimicrobial resistance is worth to consider. Aim: To assess the H. Pylori eradication rates of two different 7-day triple therapies in relation to metronidazole resistance. Methods: The study encompassed 187 trials of H. Pylori eradication in patients with peptic ulcer disease either by a) 7-day triple therapy of amoxicilline (A) 1 g bid, metronidazole (M) 500 mg bid with pantoprozole 40 mg bid or omeprazole or 20 mg bid (N = 150) or by b) 7-day metronidazole 500 mg bid, azithromycine (Az) 1 g od for 3 dyas with pantoprazole 40 mg bid or omeprazole 20 mg bid (N = 37). H. Pylori status was assessed by histology, CLO test, culture of antral and corpus biopsies and by 13C urea Breath Test (UBT). Repeat endoscopy was performed at least 28 days after the last does of study medication. Cure of H. Pylori infection was assumed if all tests were negative. Resistance was determined by E-test. Strains were considered M-resistant if MIC was >16 m. Results: H. Pylori cure Total (%) M-sensitive M-resistant a) PPI-A-M (n = 150) 100 (66.67) 83 (72.81) 17 (47.22) b) PPI-Az-M (n = 37) 26 (70.27) 18 (72.0) 8 (57.14) Conclusion: In the case of pretreatment metronidazole resistance the efficacy of two triple anti-H. Pylori therapies containing metronidazole with PPI and amoxicilline or azithromycine did not differ significantly reaching 47% and 57% eradication rate, respectively.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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