Naslov
The effect of eradicating Helicobacter Pylori infection on the course of hyperplastic gastric polyps

Autori
Ljubičić, Neven ; Banić, Marko ; Kujundžic, Milan ; Antic, Zoran ; Vrkljan, Milan ; Kovacevic, Igor ; Hrabar, Davor ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Gut 1999;45(Suppl V) / Farthing, J, G, Michael ; - London : Delhi : British Medicaj Journal, 1999

Skup
7th United European Gastroenterology Week

Mjesto i datum
Rim, Italija, 25.11.1999. - 30.11.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori; Hiperplastični želučani polipi; Eradikacijska terapija
(Helicobacter pylori; Hyperplastic gastric polyps; Eradication therapy)

Sažetak
Background: Histopathological and clinical data suggest that H. Pylori is the cause of chronic gastritis and peptic ulcer disease. However, little has been written about the potential causal relation of H. Pylori infection to hyperplastic gastric polyps. Aims: The aim of this study was to determine the effect of eradicating H. Pylori infection on the course on hyperplastic gastric polyps. Methods: Twenty-one patients with histologically proven gastric hyperplastic polyps were included in a study. Among them, 16 patients (76%) were H. Pylori positive, as assessed by histology and CLO-test. The treatment of H. Pylori infection consisted of a 2-week course of omeprazole or pantoprazole and a one-week course of metronidazole and amoxicillin or clarithromycin and amoxicillin. Control endoscopy was performed at least four weeks after treating the H. Pylori infection, and then, every 3 to 4 months. After the treatment of H. Pylori infection the median follow-up was 12 months (range, 3 to 16 months). Results: H. Pylori was completely eradicated in all patients. Disappearance or almost total regression of the hyperplastic gastric polyps was observed in 7 of the 16 H. Pylori positive patients (44%, 95%CI 19% to 68%). However, complete disappearance was evident in only 2 of the 7 patients at the first endoscopy after the treatment of H. Pylori infection. The endoscopic snare polypectomy was done in nine patients in whom disappearance or almost total regression of the gastric polyp was not observed after H. Pylori eradication, as well as in five patients with hyperplastic gastric polyps who were negative for H. Pylori. During the follow-up period no gastric polyp recurrence was observed. Conclusions: Our results suggest that the cure of H. Pylori infection associated with hyperplastic gastric polyps resulted in complete polyp regression in more than 40% of patients. Therefore, for patients with hyperplastic gastric polyps and concurrent H. Pylori infection an antibiotic treatment designed to eradicate H. Pylori appears to be recommended before further therapeutic options are considered.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA