Naslov
Helicobacter Pylori infection in patients with liver cirrhosis

Autori
Naumovski-Mihalić, Slavica ; Čolić-Cvrlje, Vesna ; Prskalo, Marija ; Šabarić, Branka ; Tićak, Mirjana ; Papa, Branko ; Filipec, Tajana ; Škurla, Bruno ; Katičić, Miroslava

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Gut 2000 ; 47(Suppl III) / - London : Delhi : British Medicaj Journal, 2000

Skup
8th United European Gastroenterology Week

Mjesto i datum
Bruxelles, Belgija, 25.11.2000. - 30.11.2000

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori; ciroza jetre; encefalopatija; krvarenje
(Helicobacter pylori; liver cirrhosis; encephalopathy; bleeding)

Sažetak
Aim: The aim of our study was to investigate the possible pathogenetic role of Helicobacter pylori (HP) infection in patients with cirrhosis of the liver. Patients and methods: 235 patients (M/F 155/80, aged 24-86 Yr.) suffered from liver cirrhosis, were hospitalised during five years in Intensive Care Unit, University Hospital Merkur in Zagreb. They were divided into three groups according to the Childs classification (A, B and C) - presence or absence of each of the following: ascites, splenomegaly, oesophageal varices, bilirubin level and known risk factor for hepatic encephalopathy (gastrointestinal bleeding, azothemia, hepatorenal syndrome, infection and severity of disease). All patients had upper gastro-intestinal endoscopy and the gastroduodenal pathology was identified. Helicobacter pylori (HP) infection was confirmed by gastric histology. Results: 143 (60, 85%) patients were HP positive. 79 (33, 61%) patients were admitted because of upper GI bleeding. In this group, 61 (77, 21%) were HP positive (X2 test 13.38, p=0.003, CI= 0.32-0.42). The highest rates of HP infection were found among patients in Childs class C. We found significant difference in HP positive rate between the patients with and without oesophageal varices too. 113 (69, 36%) patients had encephalopathy, and 88 (77, 87%) of those were infected with HP, compared with only 48, 3% patients without encephalopathy (X2 test 17.58, p=0.002 CI= 0.54-0.62). Conclusion: According to our results we found that HP infection was higher among patients with cirrhosis and acute GI bleeding, as well as with Childs class C group. HP positive patients have been in higher risk for hepatic encephalopathy too.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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