Pregled bibliografske jedinice broj: 50339
DNA topoisomerase I and repair of genomic damage
DNA topoisomerase I and repair of genomic damage // Current Studies of Biotechnology / Zlatko, Kniewald i ost. (ur.).
Zagreb: Hrvatsko biotehnološko društvo, 2000. str. 15-18 (predavanje, domaća recenzija, cjeloviti rad (in extenso), znanstveni)
CROSBI ID: 50339 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
DNA topoisomerase I and repair of genomic damage
Autori
Nagy, Biserka ; Furčić, Ivana
Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni
Izvornik
Current Studies of Biotechnology
/ Zlatko, Kniewald i ost. - Zagreb : Hrvatsko biotehnološko društvo, 2000, 15-18
Skup
Biotechnology and Biomedicine with international participation
Mjesto i datum
Zagreb, Hrvatska, 22.02.1999. - 23.02.1999
Vrsta sudjelovanja
Predavanje
Vrsta recenzije
Domaća recenzija
Ključne riječi
Xeroderma pigmentosum cells; topoisomerase I activity; DNA damage
Sažetak
Recent evidence indicates that unrepaired genomic damage influences the catalytic activities of DNA topoisomerases. DNA lesions such as base mismatches, pyrimidinic dimers, 6, 4-photoproducts, apurinic and apyrimidinic sites and others, enhance topoisomerase I mediated DNA cleavage. These findings suggest that topoisomerase activity can be influenced by spontaneous, as well as environmentally induced damages to DNA. In this study the catalytic activity of topoisomerase I was examined Xeroderma pigmentosum cell lines B and C and compared with the activity of normal human cells. The data show that topoisomerase I levels are higher in two repair-deficient cell lines. This provide novel insight into the mechanism of action of topoisomerases and raise new questions regarding mechanism of topoisomerase-targeting drugs.
Izvorni jezik
Engleski
Znanstvena područja
Biologija
