Naslov
Sinteza i antitumorska aktivnost novih benzimidazola i benzimidazo[1, 2-a]kinolina
(Synthesis and antitumor activity of novel benzimidazoles and benzimidazo[1, 2-a]quinolines)

Autori
Hranjec, Marijana ; Perin, Nataša ; Uzelac, Lidija ; Kralj, Marijeta ; Karminski-Zamola, Grace

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXII. Hrvatski skup kemičara i kemijskih inženjera -Knjiga sažetaka / Tomašić Vesna, Maduna Valkaj Karolina - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2011, 142-142

ISBN
978-953-6894-42-0

Skup
XXII. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Zagreb, Hrvatska, 13.02.2011. - 16.02.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
benzimidazoli; benzimidazo[1; 2-a]kinolini; antitumorska aktivnost
(benzimidazoles; benzimidazo[1; 2-a]quinolines; antitumor activity)

Sažetak
Over the past few years substituted benzimidazoles and their azino fused derivatives have been one of the most extensively studied classes of heterocyclic compounds and the constant and growing interest for their synthesis is owed mostly to their well known biological activities. Besides the fact that benzimidazoles are widely incorporated in the structure of numerous important medical and biochemical agents, they have the structural similarity with some naturally occurring compounds such as purine and can easily interact with biomolecules of the living systems [1, 2]. This work presents, as a part of our continuing research in the field of medicinal chemistry, the synthesis of novel nitro- and amino-substituted benzimidazoles and benzimidazo[1, 2-a]quinolines as a potential biologically active agents [3]. Antitumor activity in vitro of prepared compounds was tested on several human tumour cell lines. All tested compounds showed strong antiproliferative effect on most tested cell lines derived from different cancer types.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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