Naslov
Novi heterocikli iz reda benzotiazola ; sinteza i antitumorska aktivnost
(New heterocycles from benzothiazole series ; sythesis and antitumor activity)

Autori
Karminski-Zamola, Grace

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, pp prezentacija, znanstveni

Izvornik
22. hrvatski skupa kemičara i kemijskih inženjera : knjiga sažetaka / Tomašić, Vesna - Zagreb, 2011

Skup
Hrvatski skup kemičara i kemijskih inženjera (22 ; 2011)

Mjesto i datum
Zagreb, Hrvatska, 13.02.2011. - 16.02.2011

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
benzotiazoli; antitumorska aktivnost
(benzothiazoles; antitumor activity)

Sažetak
Novi heterocikli iz reda benzotiazola : sinteza i antitumorska aktivnost = new heterocycles from benzothiazole series : sythesis and antitumor activity / Grace Karminski-Zamola, Faculty of Chemical Engineering and Technology, Department of Organic Chemistry, Marulićev trg 20, HR-10000 Zagreb ; gzamola@fkit.hr Despite major breakthroughs in diagnosis and treatment, cancer is still the second leading cause of death in the Western world. The discovery and development of new, more active, more selective, and less toxic compounds for the treatment of malignancy are one of the most important goals in medicinal chemistry. Newly synthesized benzothiazoles demonstrate interesting pharmacological activities and led to development of new medications for treating diseases. They were studied extensively for their antiallergic, anti-inflammatory, , 10 antitumor11-14 and other biological activities.15, 16 The above considerations prompted us to design and synthesize a new series of amidino-substituted benzothiazole derivatives (Figure 1) and to test their antiproliferative activity of tumor cells in vitro. [1] Ban, M. ; Taguchi, H. ; Katsushima, T. ; Takahashi, M. ; Shinoda, K. ; Watanabe, A. ; Tominaga, T. Bioorg. Med. Chem. 1998, 6, 1069–1076. [2] Papadopoulou, C. ; Geronikaki, A. ; Hadjipavlou-Litina, D. Farmaco 2005, 60, 969–973. [3] Chung, Y. ; Shin, Y.-K. ; Zhan, C.-G. ; Lee, S. ; Cho, H. Arch.Pharmacal Res. 2004, 27, 893–900. [4] Ćaleta I. ; Kralj M. ; Marjanović M. ; Branimir Bertoša B. ; Tomić S. ; Pavlović G. ; Pavelić K. and Karminski-Zamola G. J. Med. Chem., 2009, 52, 1744-1756 [5].Racane L. ; Tralić-Kulenović V. ; Kraljević Pavelić S. ; Ratkaj I. ; Peixoto P. ; Nhili R. ; Depauw S. ; Hildebrand MP. ; David-Cordonnier MH. ; Pavelić K. and Karminski-Zamola G, J. Med. Chem. 2010, 53, 2418-2432

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija

Napomena
Rad je usmeno prezentiran na engleskom jeziku

POVEZANOST RADA