Naslov
Synthesis and anti-inflammatory activity of 1-thia-dibenzo[e, h]azulenes modified at position 8

Autori
Ozimec Landek, Ivana ; Pešić, Dijana ; Stanić, Barbara ; Hrvačić, Boška ; Merćep, Mladen ; Mesić, Milan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
1st European Workshop in Drug Synthesis

Mjesto i datum
Castelnuovo Berardenga, Italija, 14.05.2006. - 19.05.2006

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
1-thia-8-oxa-dibenzo[e; h]azulenes; 1; 8-dithia-dibenzo[e; h]azulenes; 8H-1-thia-8-aza-dibenzo[e; h]azulenes; 8H-2-thia-dibenzo[e; h]azulenes

Sažetak
1-Thia-dibenzo[e, h]azulene derivatives were found to be new potent molecules with antiinflammatory activity. One of the main research goals was to investigate the way modifications of different sites at 1-thia-dibenzo[e, h]azulene scaffold affect biological activity. The most obvious and synthetically very interesting modification appeared to be exchange of different heteroatoms (O, S and N) and CH2 group at position 8. We have searched for the most efficient and economic route, which would use the common synthetic intermediate as early as possible. Antiinflammatory activity of target molecules was determined in vitro and in vivo as inhibition of the key proinflammatory cytokine tumor necrosis factor alpha (TNF-alpha).

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti

POVEZANOST RADA