Naslov
Design, Synthesis and Characterization of Some Novel 3-Coumarinyl- 5-aryliden-1, 3-thiazolidine-2, 4-diones and Their Antioxidant Activity

Autori
Čačić, Milan ; Molnar, Maja

Izvornik
Zeitschrift für Naturforschung. B, A journal of chemical sciences (0932-0776) 66b (2011), 1; 177-183

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
1; 3-Thiazolidine-2; 4-diones; 7-Hydroxy-4-bromomethyl-2-oxo-2H-chromene; Knoevenagel Reaction; N-Substitution; Antioxidant Activity

Sažetak
In our effort to obtain biologically active compounds, new 3, 5-disubstituted 1, 3-thiazolidine-2, 4- diones (5a – r) were synthesized. A series of 5-arylmethylidene-1, 3-thiazolidine-2, 4-diones (3a – r) were prepared by Knoevenagel reaction from 1, 3-thiazolidine-2, 4-dione (2) and appropriate aromatic aldehydes. Condensation of 3a – r with 7-hydroxy-4-bromomethyl-2-oxo-2H-chromene (1) afforded novel 3-(7-hydroxy-2-oxo-2H-chromen-4-ylmethyl)-5-arylidene-1, 3-thiazolidine-2, 4-diones 5a – r. Compounds 3a – r and 5a – r were evaluated for their antioxidant activity (DPPH free radical scavenging activity).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA