Naslov
IMP3, a proposed novel basal phenotype marker, is commonly over-expressed in adenoid cystic carcinomas but not in apocrine carcinomas of the breast.

Autori
Vranic, Semir ; Gurjeva, Olga ; Frkovic-Grazio, Snjezana ; Palazzo, Juan ; Tawfik, Ossama ; Gatalica, Zoran

Izvornik
Applied immunohistochemistry & molecular morphology (1541-2016) 19 (2011), 5; 413-416

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adenoid cystic carcinoma ; apocrine carcinoma ; breast ; IMP3

Sažetak
IMP3 (IGF-II mRNA-binding Protein 3) is a member of the insulin-like growth factor-II signaling pathway, and has recently been described as a biomarker of basal-like breast carcinomas. This study explored IMP3 expression in adenoid cystic carcinomas of the breast, a special type of basal- like, triple- negative (Estrogen receptor/Progesterone Receptor/Her-2/neu protein negative) carcinoma and compared it with a group of apocrine carcinomas, which are an example of ER/PR negative, special type of breast carcinoma. Eighteen breast adenoid cystic carcinomas (16 primary and two corresponding metastases) and eighteen apocrine carcinomas, (16 invasive and two in situ) were evaluated for the expression of IMP3 protein using immunohistochemical method. A cutoff value for IMP3 positivity was set at 10%. Thirteen out of 16 (81.3%) primary adenoid cystic carcinomas over-expressed IMP3 protein, predominantly in membranous distribution. The mean percentage of positive cells among primary adenoid cystic carcinomas was 50%. Both metastatic adenoid cystic carcinomas also strongly overexpressed IMP3 protein (70% and 80% of the tumor cells, respectively). In contrast, only four out of 16 invasive apocrine carcinomas (25%) exhibited IMP3 positivity with significantly lower percentage of positive cells (27%, p<0.001). Two in-situ apocrine carcinomas were negative. Our results indicate that IMP3 may be an additional basal-type marker in breast carcinoma whose expression can be occasionally seen in other types of breast carcinomas such as apocrine type.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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