Naslov
HOW IMPORTANT ARE DIFFERENT MARKERS OF MYOCARDIAL DAMAGE AND INFLAMMATION IN PATIENTS WITH ACUTE CORONARY SYNDROMES?

Autori
Babić, Zdravko ; Nikolić Heitzler, Vjeran ; Bulj, Nikola ; Radeljić, Vjekoslav ; Pavlov, Marin ; Erdeljić, Viktorija ; Mihatov, Šime.

Izvornik
Kardiologia (1210-0048) 14 (2005); K/C90-K/C90

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, ostalo

Ključne riječi
MARKERS OF MYOCARDIAL DAMAGE; MARKERS OF INFLAMMATION; ACUTE CORONARY SYNDROMES

Sažetak
INTRODUCTION: Inflammatory process are linked to ischemic myocadial damage and necrosis.Myocardial damage markers (i.e. troponin T, CK) and markers of inflammation (CRP and fibrinogen) have been proven to be reliable and important markers of risk in ischemic heart disease.BNP, IL-6 and sICAM are also risk markers in acute coronary syndromes.According to literature Troponin T and CRP are strongly related to the long-term risk of cardiac death as independent risk factors. Fibrinogen level was associated both with the short-and long-term risk of death and/or subsequent MI in FRISC and TIMI III trials. AIM OF THE STUDY: Comparison of predictive values of variables of myocardial necrosis (Troponin T and CK) and inflammation (CRP and fibrinogen) in acute coronary syndromes (ACS). METHODS: Comparison of peak values of troponin T, CK, CRP and fibrinogen with ECG changes, echocardiography and coronarography findings, early and late complications, number of days of hospitalization, and in-hospital mortality in ACS patients. INVESTIGATED PATIENTS:120 patients who suffered ACS (STEMI, NSTEMI, UA) and were hospitalized in CCU, Department of Cardiovascular Diseases, Clinical Hospital “Sestre milosrdnice”, Zagreb, Croatia. CONCLUSION:According to this results, myocardial demage markers troponin T and CK were the most predictive markers in patients with ACS, while predictive value of CRP was lower. In this investigation, fibrinogen indicated no predictive value in patients with ACS.

Izvorni jezik
Engleski

POVEZANOST RADA