Naslov
The usefulness of biochemical bone markers in predicting the response of hormone replacement therapy in perimenopausal cigarette smoking healthy women

Autori
Čubrilo-Turek, Mirjana ; Stavljenić-Rukavina, Ana ; Turek, Stjepan ; Kušec, Vesna ; Duraković, Zijad

Izvornik
Collegium Antropologicum (0350-6134) 23 (1999), 1; 195-201

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone markers; hormone therapy; smoking; women

Sažetak
The purpose of the study was to evaluate the effects of orally administered combined sequential estradiol(2 mg 17-beta estradiol) with progestin(1 mg norethisteron acetate) daily during 15.34 +/- months on bone markers in perimenopausal cigarette smoking women. The control group consisted of cigarette smoking perimenopausal women without hormone replacement therapy (HRT). The following biochemical bone markers were analyzed in horm one replacement users(N=35) and non-users (N=28): serum total calcium(CA), total alkaline phosphatase (ALP), procollagen 1 C-terminal propeptide (PICP), cros linked carboxyterminal collagen I telopeptide(ICTP) and osteocalcin(OC). When we compared the results of bone markers in the cigarette smoking current users and non cigarette smoking non-users, we found statistically significant lower levels of bone formation markers, ALP and OC, and lower level of bone resorption marker: ICTP in users than in non-users. In perimenopausal cigarette smoking women on HRT lower levels of new biological markers reflecked less intensive bone remodelling and probable decrease in bone loss than in non-users. The results indicate that the measurement of biological bone markers are useful to identify risk women for osteoporosis who may have special benefit from the treatment with hormone replacement therapy, even when they smoke.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA