Naslov
Prognostic significance of carbonic anhydrase IX (CA-IX), endoglin (CD105) and 8-hydroxy-2'- deoxyguanosine (8-OHdG) in breast cancer patients

Autori
Beketić-Orešković, Lidija ; Ozretić, Petar ; Rabbani, Zahid N. ; Jackson, Isabel L. ; Šarčević, Božena ; Levanat, Sonja ; Marić, Petra ; Babić, Ivan ; Vujasković, Željko

Izvornik
Pathology and Oncology Research (1219-4956) 17 (2011), 3; 593-603

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
8-OHdG; breast cancer; CA-IX; CD105; survival analysis

Sažetak
The aim of this study was to examine the prognostic significance of carbonic anhydrase IX (CA-IX), an endogenous marker for tumor hypoxia ; endoglin (CD105), a proliferation-associated and hypoxia-inducible glycoprotein and 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidative DNA lesion, in breast cancer patients. Immunohistochemical expressions of CA-IX, CD105 and 8-OHdG, analyzed on paraffin-embedded tumor tissues from forty female breast cancer patients, were used to assess their prognostic implication on overall survival (OS) and relapse-free survival (RFS). Patients with high CA-IX expression (above cut-off value) had a higher occurrence of relapse (P=0.002). High CA-IX expression was significantly associated with shorter RFS (P<0.001, hazard ratio (HR) 0.21) and shorter OS (P<0.001, HR 0.19). Lymph node negative patients with high CA-IX expression had worse RFS (P=0.031, HR 0.14) and OS (P=0.005, HR 0.05). Patients with grade I&II tumors and high CA-IX expression showed shorter RFS (P=0.028, HR 0.28) and OS (P=0.008, HR 0.20). Worse OS (P=0.046, HR 0.28) was found in subgroup of patients with grade II tumors and high CA-IX expression. Among all three markers, only high CA-IX expression was strong independent prognostic indicator for shorter OS (HR 4.14, 95% CI 1.28-13.35, P=0.018) and shorter RFS (HR 3.99, 95% CI 1.38-11.59, P=0.011). Elevated expression of CA-IX was an independent prognostic factor for decreased RFS and OS and a significant marker for tumor aggressiveness. CD105 had week prognostic value ; whereas, 8-OHdG, in this study, did not provide sufficient evidence as a prognostic indicator in breast cancer patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA