Naslov
Developmental and environmental regulation of heterochromatin transcription

Autori
Ugarković, Đurđica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Cost Action TD09/05 Epigenetics-Bench to Bedside

Mjesto i datum
Brno, Češka Republika, 22.11.2010. - 25.11.2010

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
epigenetics; transcription; non-coding RNA; heterochromatin

Sažetak
Chromatin condensation is a way of gene silencing, as evident for the hundreds of functional protein genes harboured in heterochromatic regions. Being the major heterochromatin constituents satellite DNA sequences are supposed to play important roles in heterochromatin regulation. RNA Pol II transcription from pericentromeric satellite DNA elements occurs in all developmental stages, being the highest during embryogenesis. Satellite DNA transcripts range from small RNAs (siRNAs) to very large RNAs and preferentially remain in the nucleus. The actively regulated expression of satellite DNAs by cis or trans elements as well as by environmental stress speaks in favour of their involvement in differentiation, development and environmental stress response.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA