Naslov
Ispitivanje antioksidativne aktivnosti hidroksamskih kiselina
(Antioxidant activity of hydroxamic acid)

Autori
Petrić, Neva

Vrsta, podvrsta i kategorija rada
Ocjenski radovi, diplomski rad

Fakultet
Farmaceutsko-biokemijski fakultet

Mjesto
Zagreb

Datum
15.06

Godina
2009

Stranica
25

Mentor
Zovko Končić, Marijana

Ključne riječi
antioksidativna aktivnost; hidroksamske kiseline; antiradikalna aktivnost; beta-karoten linoleatni test
(antioxidant activit; y hydroxamic acid; antiradical activity; beta-carotene linoleate assay)

Sažetak
In the present study, seven hydroxamic acid derivatives of nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, fenoprofen, ketoprofen, indomethacin and diclofenac) were found to possess significant antioxidant, radical scavenging and metal chelating activities. The most active antioxidant and radical scavenger was N-methylhydroxamic acid of diclofenac (ANT = 88.0 % and EC50 = 60.1 mg mL– 1). The activity of the standard substance, butylated hydroxyanisole, in the two assays was ANT = 86.9 % and EC50 = 18.8 mg mL– 1, respectively. Ibuproxam was the strongest iron chelator among investigated hydroxamic acids (EC50 = 255.6 mg mL– 1), yet significantly weaker than the standard substance, EDTA (EC50 = 29.1 mg mL– 1). It seems that different mechanism is involved in metal chelating activity than in antioxidant and radical scavenging activity. Antioxidant and radical scavenging activities may be connected with conjugation of the nitrogen lone electron pair with the carbonyl group. On the other hand, more hydrophilic substances tend to be better iron chelators.

Izvorni jezik
Hrvatski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA