Pregled bibliografske jedinice broj: 495927
Synthesis of novel 3′,4′-seco analogues of didehydro dideoxy nucleosides as potential antiviral agents
Synthesis of novel 3′,4′-seco analogues of didehydro dideoxy nucleosides as potential antiviral agents // Tetrahedron letters, 35 (1994), 18; 2937-2940 doi:10.1016/S0040-4039(00)76665-2 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 495927 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis of novel 3′,4′-seco analogues of didehydro dideoxy nucleosides as potential antiviral agents
Autori
Jokić, Milan ; Škarić, Vinko
Izvornik
Tetrahedron letters (0040-4039) 35
(1994), 18;
2937-2940
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
acyclo analogues of didehydro dideoxy adenosine
Sažetak
Novel acyclo analogues (13, 14) of didehydro dideoxy adenosine (d4A) lacking C-3'-C-4' bond were synthesized as potential anti-HIV agents. The key step involves the bromination of unsaturated isomer 6 with NBS in mono protected ethylene glycol leading to 3', 4'-seco-2'-bromo-3'-hydroxy compound 11a. Activation of 3'-hydroxy group and reductive elimination of vicinal bromo tosylate gave 13 which on deprotection was converted into the target molecule 14.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Ustanove:
Institut "Ruđer Bošković", Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
