Naslov
High-Salt Diet and Hypertension : Focus on the Renin-Angiotensin System

Autori
Drenjančević-Perić, Ines ; Jelaković, Bojan ; Lombard, Julian H ; Kunert, Mary Pat ; Kibel, Aleksandar ; Gros, Mario

Izvornik
Kidney & blood pressure research (1420-4096) 34 (2011); 1-11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
hypertension; salt; sodium; renin-angiotensin system

Sažetak
A high-salt diet is one of the major risk factors in the development and maintenance of hypertension. Numerous experimental and observational studies have confirmed the association of sodium intake with blood pressure levels. The effects of a high-salt diet are related to the function of the renin-angiotensin system, which is normally suppressed by a high-salt diet. Endothelial dysfunction probably plays an important role in the influence of high sodium intake on blood pressure, although the exact mechanisms remain elusive. Genetic factors are known to be very important, and various consomic and congenic rat strains as animal models have proven to be very useful in bringing us a step closer to understanding the interaction between salt intake and hypertension. In this article, experimental data obtained in studies on animals and humans, as well as epidemiological data are reviewed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA